P29376 | LTK_HUMAN | Leukocyte tyrosine kinase receptor (LTK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 511~777 | |
| PF12810 | ALK_LTK_GRD - ALK/LTK, Glycine-rich domain | 116~357 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3301622 |  |
IC50 | = | 0.35 | nM | 552.72 | CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 | Homo sapiens | CHEMBL5150862 | cell-based format |
| CHEMBL4546504 |  |
IC50 | = | 0.567 | nM | 555.99 | C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F | Homo sapiens | CHEMBL4349113 | assay format |
| CHEMBL3128069 |  |
IC50 | = | 2.0 | nM | 470.53 | Cc1nc([C@](C)(O)CO)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 | Homo sapiens | CHEMBL3129260 | single protein format |
| CHEMBL3286830 |  |
IC50 | = | 2.7 | nM | 406.42 | C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 | Homo sapiens | CHEMBL3291740 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 3.6 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3820659 | single protein format |
| CHEMBL4764610 |  |
IC50 | = | 6.3 | nM | 475.57 | COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1C[C@@H](C)N(C)[C@@H](C)C1 | Homo sapiens | CHEMBL4705529 | single protein format |
| CHEMBL1235786 |  |
IC50 | = | 29.0 | nM | 535.67 | COc1cc(N2CCC(O)CC2)ccc1Nc1cc(Nc2ccccc2S(=O)(=O)C(C)C)c2cc[nH]c2n1 | Homo sapiens | CHEMBL5212778 | single protein format |
| CHEMBL3735648 |  |
IC50 | = | 43.1 | nM | 467.61 | CC1(C)c2cc(C3CCN(CC4CCOCC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 | Homo sapiens | CHEMBL3830308 | single protein format |
| CHEMBL4067871 |  |
IC50 | = | 45.3 | nM | 467.96 | OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 | Homo sapiens | CHEMBL4018645 | single protein format |
| CHEMBL4075917 |  |
IC50 | = | 68.5 | nM | 454.51 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 | Homo sapiens | CHEMBL4018645 | single protein format |
| CHEMBL4062877 |  |
IC50 | = | 122.9 | nM | 454.51 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 | Homo sapiens | CHEMBL4018645 | single protein format |
| CHEMBL4105329 |  |
IC50 | = | 299.5 | nM | 470.96 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12 | Homo sapiens | CHEMBL4018645 | single protein format |
| CHEMBL2006765 |  |
IC50 | = | 360.0 | nM | 392.39 | CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 | Homo sapiens | CHEMBL4007721 | single protein format |
| CHEMBL3286830 | |
Ki | = | 2.7 | nM | 406.42 | C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 | Homo sapiens | CHEMBL5213165 | single protein format |