P29375 | KDM5A_HUMAN | Lysine-specific demethylase 5A (KDM5A)

Pfam Domain Table

AccessionDomainRangeColor
PF00628PHD - PHD-finger296~340
PF00628PHD - PHD-finger1164~1215
PF01388ARID - ARID/BRIGHT DNA binding domain88~170
PF02373JmjC - JmjC domain, hydroxylase470~586
PF02375JmjN - jmjN domain20~53
PF02928zf-C5HC2 - C5HC2 zinc finger676~728
PF08429PLU-1 - PLU-1-like protein741~1072
PF21323KDM5_C-hel - Lysine-specific demethylase 5, C-terminal helical domain590~644

3D structures mapped by conservation among orthologs

[ Domain: "Double-stranded beta-helix" // JmjC ]

 PyMOL session

[ Domain: "tri-helical" // ARID ]

 PyMOL session

[ Domain: "FYVE/PHD zinc finger" // PHD ]

 PyMOL session

[ Domain: "LIM domain-like" // zf-C5HC2 ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3786038 IC50 = 2.3 nM 350.38 CCc1c(C)[nH]c2c(-c3cnn(-c4cc(CO)ccn4)c3)cnn2c1=O Homo sapiens CHEMBL3789200 cell-based format
CHEMBL4228806 IC50 = 3.0 nM 384.41 CN(C)CCc1cnn(-c2cc(C(=O)O)ccn2)c1OCc1ccc(F)cc1 Homo sapiens CHEMBL4223290 single protein format
CHEMBL4229271 IC50 = 4.0 nM 320.31 N#Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 Homo sapiens CHEMBL4223290 single protein format
CHEMBL4542928 IC50 = 4.37 nM 419.57 CCCCCCN(C)CCc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 Homo sapiens CHEMBL4424782 cell-based format
CHEMBL5272926 IC50 = 4.37 nM 419.57 CCCCCCCN(C)Cc1ccc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cc1 Homo sapiens CHEMBL5237438 single protein format
CHEMBL4594120 IC50 = 5.3 nM 268.28 CC(C)c1c(-c2cn[nH]c2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL4427147 single protein format
CHEMBL4548921 IC50 = 5.6 nM 344.38 CC(C)c1c(-c2cnn(-c3ccccc3)c2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL4427147 single protein format
CHEMBL4226978 IC50 = 6.0 nM 374.19 O=C(O)c1ccnc(-n2nccc2OCc2ccc(Br)cc2)c1 Homo sapiens CHEMBL4223290 single protein format
CHEMBL4518175 IC50 = 6.2 nM 268.28 CC(C)c1c(-c2ccco2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL4427147 single protein format
CHEMBL4469253 IC50 = 7.9 nM 308.35 CC(C)c1c(-c2cnn(C3CC3)c2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL4427147 single protein format
CHEMBL4435805 IC50 = 9.2 nM 290.33 N#Cc1cnn2c(=O)c(C3CCC3)c(-c3ccccc3)[nH]c12 Homo sapiens CHEMBL4427147 single protein format
CHEMBL4468119 IC50 = 9.3 nM 216.24 Cc1[nH]c2c(C#N)cnn2c(=O)c1C(C)C Homo sapiens CHEMBL4427147 single protein format
CHEMBL4525674 IC50 = 9.5 nM 230.27 CCc1[nH]c2c(C#N)cnn2c(=O)c1C(C)C Homo sapiens CHEMBL4427147 single protein format
CHEMBL4468139 IC50 = 10.0 nM 280.29 CC(C)c1c(-c2cncnc2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL4427147 single protein format
CHEMBL5277258 IC50 = 10.0 nM 387.83 CC(C)c1c(-c2cnn(CCNC(=O)CCl)c2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL5237427 single protein format
CHEMBL4444473 IC50 = 10.1 nM 321.34 CC(C)c1c(-c2cnn(CCC#N)c2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL4427147 single protein format
CHEMBL4464271 IC50 = 10.4 nM 326.36 COCCn1cc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cn1 Homo sapiens CHEMBL4427147 single protein format
CHEMBL4538785 IC50 = 11.0 nM 281.28 CCc1c(-c2ccc(=O)[nH]c2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL4427931 single protein format
CHEMBL4587659 IC50 = 11.1 nM 296.33 CCn1cc(-c2[nH]c3c(C#N)cnn3c(=O)c2C(C)C)cn1 Homo sapiens CHEMBL4427147 single protein format
CHEMBL4542354 IC50 = 11.2 nM 322.37 CC(C)c1c(-c2cnn(C3CCC3)c2)[nH]c2c(C#N)cnn2c1=O Homo sapiens CHEMBL4427147 single protein format