P29371 | NK3R_HUMAN | Neuromedin-K receptor (TACR3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 102~356 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL374354 |  |
IC50 | = | 0.85 | nM | 445.52 | COc1c(-c2ccccc2)nc2ccccc2c1C(=O)NN(c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL912491 | cell-based format |
| CHEMBL27463 |  |
IC50 | = | 1.5 | nM | 577.6 | CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 | Homo sapiens | CHEMBL750066 | single protein format |
| CHEMBL3545233 |  |
IC50 | = | 1.6 | nM | 459.57 | CC[C@H](NC(=O)c1c(NS(C)(=O)=O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL3816399 | cell-based format |
| CHEMBL374307 |  |
IC50 | = | 1.6 | nM | 585.71 | COC(=O)N(NC(=O)c1c(CN2CCN(Cc3ccccc3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL221238 |  |
IC50 | = | 1.9 | nM | 595.77 | COC(=O)N(NC(=O)c1c(CN2CCN(C3CCSCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL221237 |  |
IC50 | = | 2.0 | nM | 577.73 | COC(=O)N(NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL10188 |  |
IC50 | = | 2.4 | nM | 382.46 | CC[C@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL912491 | cell-based format |
| CHEMBL26831 |  |
IC50 | = | 2.6 | nM | 561.6 | O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 | Homo sapiens | CHEMBL750066 | single protein format |
| CHEMBL220963 |  |
IC50 | = | 3.3 | nM | 579.7 | COC(=O)N(NC(=O)c1c(CN2CCN(C3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL375638 |  |
IC50 | = | 3.5 | nM | 597.69 | COC(=O)N(NC(=O)c1c(CN2CCN(C3CCOCC3)CC2)c(-c2ccccc2)nc2c(F)cccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL3813763 |  |
IC50 | = | 3.9 | nM | 475.57 | CC[C@H](NC(=O)c1c(NS(C)(=O)=O)c(-c2ccccc2O)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL3816399 | cell-based format |
| CHEMBL221445 |  |
IC50 | = | 4.0 | nM | 569.68 | COC(=O)N(NC(=O)c1c(CN2CCN(C(C)(C)C)CC2)c(-c2ccccc2)nc2c(F)cccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL218421 |  |
IC50 | = | 4.1 | nM | 445.45 | COC(=O)N(NC(=O)c1c(OC)c(-c2ccccc2)nc2c(F)cccc12)c1ccccc1 | Homo sapiens | CHEMBL912491 | cell-based format |
| CHEMBL4108623 |  |
IC50 | = | 5.0 | nM | 420.5 | CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 | Homo sapiens | CHEMBL3888926 | assay format |
| CHEMBL1277892 |  |
IC50 | = | 5.2 | nM | 367.45 | CCC(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccn1 | Homo sapiens | CHEMBL1285944 | cell-based format |
| CHEMBL3814787 |  |
IC50 | = | 5.6 | nM | 398.53 | CC[C@H](NC(=O)c1c(S)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL3816399 | cell-based format |
| CHEMBL221444 |  |
IC50 | = | 5.7 | nM | 578.71 | COC(=O)N(NC(=O)c1c(CC2CCN(C3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL220803 |  |
IC50 | = | 5.8 | nM | 555.65 | COC(=O)N(NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2c(F)cccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL218639 |  |
IC50 | = | 5.8 | nM | 537.66 | COC(=O)N(NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL910703 | cell-based format |
| CHEMBL3813719 |  |
IC50 | = | 6.0 | nM | 398.46 | CC[C@H](NC(=O)c1c(O)c(-c2ccccc2O)nc2ccccc12)c1ccccc1 | Homo sapiens | CHEMBL3816399 | cell-based format |