P29323 | EPHB2_HUMAN | Ephrin type-B receptor 2 (EPHB2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 326~423 | |
| PF00041 | fn3 - Fibronectin type III domain | 439~523 | |
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 911~975 | |
| PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 21~197 | |
| PF07699 | Ephrin_rec_like - Tyrosine-protein kinase ephrin type A/B receptor-like | 268~302 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 621~880 | |
| PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 544~617 | |
| PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 198~256 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]
[ Domain: "SAM domain-like" // SAM_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL566515 |  |
IC50 | = | 1.2 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046778 | single protein format |
| CHEMBL3752910 |  |
IC50 | = | 2.5 | nM | 503.49 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C | Homo sapiens | CHEMBL5212800 | assay format |
| CHEMBL4568087 |  |
IC50 | = | 2.9 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479718 | assay format |
| CHEMBL5416410 |  |
IC50 | = | 4.4 | nM | 506.03 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O | Homo sapiens | CHEMBL1244584 | single protein format |
| CHEMBL288441 |  |
IC50 | = | 8.5 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL1244584 | single protein format |
| CHEMBL4569508 |  |
IC50 | < | 10.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479718 | assay format |
| CHEMBL1289494 |  |
IC50 | = | 17.5 | nM | 454.87 | COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC | Homo sapiens | CHEMBL3429407 | single protein format |
| CHEMBL3426225 |  |
IC50 | = | 26.0 | nM | 576.63 | CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 | Homo sapiens | CHEMBL3429877 | single protein format |
| CHEMBL3426917 |  |
IC50 | = | 26.8 | nM | 460.91 | [2H]C([2H])([2H])Oc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC([2H])([2H])[2H] | Homo sapiens | CHEMBL3429407 | single protein format |
| CHEMBL4550702 |  |
IC50 | = | 36.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479718 | assay format |
| CHEMBL445162 |  |
IC50 | = | 50.0 | nM | 418.86 | CS(=O)(=O)c1cccc(Nc2nccc(Nc3c(Cl)ccc4c3OCO4)n2)c1 | Homo sapiens | CHEMBL932337 | single protein format |
| CHEMBL4638981 |  |
IC50 | = | 70.8 | nM | 507.99 | Cc1ccc(C(=O)Nc2ccc(CN3Cc4cn[nH]c4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4605665 | single protein format |
| CHEMBL1271376 |  |
IC50 | = | 82.0 | nM | 460.37 | CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(-c2cccc(CC(N)=O)c2)n1 | Homo sapiens | CHEMBL1274779 | single protein format |
| CHEMBL4640297 |  |
IC50 | = | 93.2 | nM | 524.03 | Cc1ccc(C(=O)Nc2ccc(CN3CCC4C=NNC4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 | Homo sapiens | CHEMBL4605665 | single protein format |
| CHEMBL103667 |  |
IC50 | = | 160.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL1932848 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 198.8 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3820484 | single protein format |
| CHEMBL3596879 |  |
IC50 | = | 880.0 | nM | 433.47 | Cn1cc(-c2cncc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)on4)c3)n2)cn1 | Homo sapiens | CHEMBL3598607 | single protein format |