P29322 | EPHA8_HUMAN | Ephrin type-A receptor 8 (EPHA8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 330~421 | |
| PF00041 | fn3 - Fibronectin type III domain | 440~529 | |
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 934~992 | |
| PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 33~204 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 635~892 | |
| PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 543~632 | |
| PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 205~262 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]
[ Domain: "SAM domain-like" // SAM_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3752910 |  |
IC50 | = | 1.2 | nM | 503.49 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C | Homo sapiens | CHEMBL5212798 | assay format |
| CHEMBL4568087 |  |
IC50 | = | 2.9 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479717 | assay format |
| CHEMBL566515 |  |
IC50 | = | 4.5 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046776 | single protein format |
| CHEMBL4569508 |  |
IC50 | = | 21.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479717 | assay format |
| CHEMBL4550702 |  |
IC50 | = | 29.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479717 | assay format |
| CHEMBL5088153 |  |
IC50 | = | 101.0 | nM | 575.07 | Cc1cc(NC(=O)Nc2cc(C(C)(C)C)nn2-c2ccc(Cl)cc2)ccc1Nc1ncnc2c1OC(C)(C)C(=O)N2 | Homo sapiens | CHEMBL5045158 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 137.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328403 | single protein format |
| CHEMBL4281823 |  |
IC50 | = | 233.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261409 | single protein format |
| CHEMBL1916891 |  |
IC50 | = | 434.0 | nM | 432.5 | Cc1ccccc1Nc1nc2cc(F)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 | Homo sapiens | CHEMBL1919258 | single protein format |
| CHEMBL103667 |  |
IC50 | < | 1000.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL4602918 | single protein format |