P29320 | EPHA3_HUMAN | Ephrin type-A receptor 3 (EPHA3)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00041 | fn3 - Fibronectin type III domain | 327~421 | |
PF00041 | fn3 - Fibronectin type III domain | 446~526 | |
PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 31~202 | |
PF07647 | SAM_2 - SAM domain (Sterile alpha motif) | 908~973 | |
PF07699 | Ephrin_rec_like - Tyrosine-protein kinase ephrin type A/B receptor-like | 269~303 | |
PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 622~878 | |
PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 545~618 | |
PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 203~259 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL3752910 | IC50 | = | 0.3 | nM | 503.49 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C | Homo sapiens | CHEMBL5212793 | assay format | |
CHEMBL1784637 | IC50 | = | 1.2 | nM | 582.63 | CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C | Homo sapiens | CHEMBL1785578 | single protein format | |
CHEMBL2336005 | IC50 | = | 5.1 | nM | 417.53 | Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1 | Homo sapiens | CHEMBL3707650 | cell membrane format | |
CHEMBL4568087 | IC50 | = | 22.0 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479716 | assay format | |
CHEMBL566515 | IC50 | = | 40.0 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046772 | single protein format | |
CHEMBL388978 | IC50 | = | 48.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL972534 | single protein format | |
CHEMBL4550702 | IC50 | = | 52.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479716 | assay format | |
CHEMBL4569508 | IC50 | = | 180.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479716 | assay format | |
CHEMBL4793380 | IC50 | = | 552.0 | nM | 423.48 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 | Homo sapiens | CHEMBL4767025 | single protein format | |
CHEMBL103667 | IC50 | < | 1000.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL4602916 | single protein format |