P29320 | EPHA3_HUMAN | Ephrin type-A receptor 3 (EPHA3)

Pfam Domain Table

AccessionDomainRangeColor
PF00041fn3 - Fibronectin type III domain327~421
PF00041fn3 - Fibronectin type III domain446~526
PF01404Ephrin_lbd - Ephrin receptor ligand binding domain31~202
PF07647SAM_2 - SAM domain (Sterile alpha motif)908~973
PF07699Ephrin_rec_like - Tyrosine-protein kinase ephrin type A/B receptor-like269~303
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase622~878
PF14575EphA2_TM - Ephrin type-A receptor 2 transmembrane domain545~618
PF25599Ephrin_CRD - Ephrin cysteine rich domain203~259

3D structures mapped by conservation among orthologs

[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3752910 IC50 = 0.3 nM 503.49 Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C Homo sapiens CHEMBL5212793 assay format
CHEMBL1784637 IC50 = 1.2 nM 582.63 CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C Homo sapiens CHEMBL1785578 single protein format
CHEMBL2336005 IC50 = 5.1 nM 417.53 Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1 Homo sapiens CHEMBL3707650 cell membrane format
CHEMBL4568087 IC50 = 22.0 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479716 assay format
CHEMBL566515 IC50 = 40.0 nM 417.43 COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 Homo sapiens CHEMBL1046772 single protein format
CHEMBL388978 IC50 = 48.0 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL972534 single protein format
CHEMBL4550702 IC50 = 52.0 nM 406.39 Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479716 assay format
CHEMBL4569508 IC50 = 180.0 nM 529.59 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 Homo sapiens CHEMBL4479716 assay format
CHEMBL4793380 IC50 = 552.0 nM 423.48 CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 Homo sapiens CHEMBL4767025 single protein format
CHEMBL103667 IC50 < 1000.0 nM 527.67 Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 Homo sapiens CHEMBL4602916 single protein format