P29317 | EPHA2_HUMAN | Ephrin type-A receptor 2 (EPHA2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 331~420 | |
| PF00041 | fn3 - Fibronectin type III domain | 439~524 | |
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 904~966 | |
| PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 29~201 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 614~871 | |
| PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 538~610 | |
| PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 202~262 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3_9 ]
[ Domain: "SAM domain-like" // SAM_1 ]
[ Domain: "SAM domain-like" // UNK_F_TYPE ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "EGF/Laminin" // KOG0196 ]
[ Domain: "EGF/Laminin" // KOG0196,Laminin_EGF ]
[ Domain: "EGF/Laminin" // Laminin_EGF_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1784637 |  |
IC50 | = | 0.6 | nM | 582.63 | CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C | Homo sapiens | CHEMBL1785577 | single protein format |
| CHEMBL566515 |  |
IC50 | = | 2.3 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046771 | single protein format |
| CHEMBL3752910 |  |
IC50 | = | 3.0 | nM | 503.49 | Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C | Homo sapiens | CHEMBL5210123 | assay format |
| CHEMBL1688861 |  |
IC50 | = | 11.0 | nM | 538.57 | CC(C)(N)c1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL1693591 | single protein format |
| CHEMBL478629 |  |
IC50 | = | 11.0 | nM | 399.5 | c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 | Homo sapiens | CHEMBL1272380 | single protein format |
| CHEMBL4466555 |  |
IC50 | = | 13.5 | nM | 514.9 | Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 | Homo sapiens | CHEMBL4331422 | single protein format |
| CHEMBL3426225 |  |
IC50 | = | 16.0 | nM | 576.63 | CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 | Homo sapiens | CHEMBL3429876 | single protein format |
| CHEMBL1688860 |  |
IC50 | = | 18.0 | nM | 538.57 | CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL1693591 | single protein format |
| CHEMBL3577124 |  |
IC50 | = | 20.0 | nM | 424.52 | CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 | Homo sapiens | CHEMBL3578499 | cell-based format |
| CHEMBL1081198 |  |
IC50 | = | 35.0 | nM | 503.49 | O=C(Nc1cccc(-c2cn3ccnc3c(NCc3ccncc3)n2)c1)Nc1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL1109426 | single protein format |
| CHEMBL3982666 |  |
IC50 | = | 50.0 | nM | 575.4 | COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CN(C(=O)c2cc(F)ccc2F)CCO1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3942387 |  |
IC50 | = | 50.0 | nM | 533.46 | COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CN(C(=O)CCC(C)C)CCO1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3959038 |  |
IC50 | = | 50.0 | nM | 561.51 | CCCC(CCC)C(=O)N1CCOC(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)C1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3986123 |  |
IC50 | = | 50.0 | nM | 533.46 | CCCC(C)C(=O)N1CCOC(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)C1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3945062 |  |
IC50 | = | 50.0 | nM | 583.47 | COc1cccc(CC(=O)N2CCOC(COc3cc4ncnc(Nc5ccc(Cl)c(Cl)c5)c4cc3OC)C2)c1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3933897 |  |
IC50 | = | 50.0 | nM | 487.39 | CC#CCN1CCOC(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)C1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3893845 |  |
IC50 | = | 50.0 | nM | 555.48 | CCCCS(=O)(=O)N1CCOC(COc2cc3ncnc(Nc4ccc(Cl)c(Cl)c4)c3cc2OC)C1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3923692 |  |
IC50 | = | 50.0 | nM | 575.9 | COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CN(S(=O)(=O)CCCCl)CCO1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3901787 |  |
IC50 | = | 50.0 | nM | 589.5 | COc1cc2c(Nc3ccc(Cl)c(Cl)c3)ncnc2cc1OCC1CN(S(=O)(=O)Cc2ccccc2)CCO1 | Homo sapiens | CHEMBL3883065 | assay format |
| CHEMBL3939874 |  |
IC50 | = | 50.0 | nM | 528.39 | COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(/C(N)=N/C#N)CC1 | Homo sapiens | CHEMBL3883065 | assay format |