P29275 | AA2BR_HUMAN | Adenosine receptor A2b (ADORA2B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 24~290 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL483688 |  |
IC50 | = | 0.739 | nM | 529.02 | CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O | Homo sapiens | CHEMBL4189485 | cell-based format |
| CHEMBL5426527 |  |
IC50 | = | 0.8 | nM | 417.52 | COc1cccc2c1nc(N)n1nc(C3CCC(c4ccc(C(C)(C)N)cn4)C3)nc21 | Homo sapiens | CHEMBL5375926 | cell membrane format |
| CHEMBL437309 |  |
IC50 | = | 1.0 | nM | 572.49 | Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)cc5)CC4)cc3)cc2n(C)c1=O | Homo sapiens | CHEMBL864807 | cell-based format |
| CHEMBL4215606 |  |
IC50 | = | 1.06 | nM | 541.03 | CCCN1C(=O)N=C2N=C(c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)N=C2C1=O | Homo sapiens | CHEMBL4189485 | cell-based format |
| CHEMBL5413371 |  |
IC50 | = | 1.6 | nM | 417.52 | COc1cccc2c1nc(N)n1nc([C@H]3C[C@H](c4ncc(C(C)(C)N)cc4C)C3)nc21 | Homo sapiens | CHEMBL5375926 | cell membrane format |
| CHEMBL4569909 |  |
IC50 | = | 2.4 | nM | 438.55 | COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3nc[nH]c3C)sc21 | Homo sapiens | CHEMBL4422945 | cell-based format |
| CHEMBL5438060 |  |
IC50 | = | 2.7 | nM | 437.94 | COc1cccc2c1nc(N)n1nc([C@H]3C[C@H](c4ncc(C(C)(C)N)cc4Cl)C3)nc21 | Homo sapiens | CHEMBL5375926 | cell membrane format |
| CHEMBL5430246 |  |
IC50 | = | 2.9 | nM | 385.43 | COc1cccc2c1nc(N)n1nc(C3CC3c3nc4ccccc4n3C)nc21 | Homo sapiens | CHEMBL5375926 | cell membrane format |
| CHEMBL5413330 |  |
IC50 | = | 3.1 | nM | 386.46 | COc1cccc2c1nc(N)n1nc(C3CC3c3ccc4c(c3)CCNC4)nc21 | Homo sapiens | CHEMBL5375926 | cell membrane format |
| CHEMBL5426841 |  |
IC50 | = | 3.3 | nM | 404.47 | COc1cccc2c1nc(N)n1nc([C@H]3C[C@H](c4ccc(C(C)(C)O)cn4)C3)nc21 | Homo sapiens | CHEMBL5375926 | cell membrane format |
| CHEMBL183 |  |
IC50 | = | 3.8 | nM | 304.39 | CCCn1c(=O)c2[nH]c(C3CCCC3)nc2n(CCC)c1=O | Homo sapiens | CHEMBL4189485 | cell-based format |
| CHEMBL211813 |  |
IC50 | = | 4.0 | nM | 534.06 | Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)s5)CC4)cc3)cc2n(C)c1=O | Homo sapiens | CHEMBL864807 | cell-based format |
| CHEMBL212416 |  |
IC50 | = | 6.0 | nM | 546.65 | CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C#N)cc5)CC4)cc3)cc2n(C)c1=O | Homo sapiens | CHEMBL864807 | cell-based format |
| CHEMBL209742 |  |
IC50 | = | 6.0 | nM | 479.56 | Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5)CC4)cc3)cc2n(C)c1=O | Homo sapiens | CHEMBL864807 | cell-based format |
| CHEMBL210088 |  |
IC50 | = | 7.0 | nM | 529.57 | Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5F)CC4)cc3)cc2n(C)c1=O | Homo sapiens | CHEMBL864807 | cell-based format |
| CHEMBL210383 |  |
IC50 | = | 7.0 | nM | 511.58 | Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)cc2n(C)c1=O | Homo sapiens | CHEMBL864807 | cell-based format |
| CHEMBL4576817 |  |
IC50 | = | 8.8 | nM | 438.55 | COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3c[nH]c(C)n3)sc21 | Homo sapiens | CHEMBL4422945 | cell-based format |
| CHEMBL379217 |  |
IC50 | = | 10.0 | nM | 511.58 | Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)cc2n(C)c1=O | Homo sapiens | CHEMBL864807 | cell-based format |
| CHEMBL4521489 |  |
IC50 | = | 12.0 | nM | 424.53 | COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cn3ccnc3)sc21 | Homo sapiens | CHEMBL4422945 | cell-based format |
| CHEMBL210969 |  |
IC50 | = | 12.0 | nM | 553.66 | CCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)NC4CCN(Cc5ccc(F)cc5)CC4)cc3)cc2n(CC)c1=O | Homo sapiens | CHEMBL864807 | cell-based format |