P29274 | AA2AR_HUMAN | Adenosine receptor A2a (ADORA2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 23~288 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_3 ]
[ Domain: "Cytochromes" // Cytochrom_B562_1 ]
[ Domain: "Lysozyme-like" // Phage_lysozyme_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5430246 |  |
IC50 | = | 0.3 | nM | 385.43 | COc1cccc2c1nc(N)n1nc(C3CC3c3nc4ccccc4n3C)nc21 | Homo sapiens | CHEMBL5375925 | cell membrane format |
| CHEMBL5413371 |  |
IC50 | = | 0.6 | nM | 417.52 | COc1cccc2c1nc(N)n1nc([C@H]3C[C@H](c4ncc(C(C)(C)N)cc4C)C3)nc21 | Homo sapiens | CHEMBL5375925 | cell membrane format |
| CHEMBL5438060 |  |
IC50 | = | 0.8 | nM | 437.94 | COc1cccc2c1nc(N)n1nc([C@H]3C[C@H](c4ncc(C(C)(C)N)cc4Cl)C3)nc21 | Homo sapiens | CHEMBL5375925 | cell membrane format |
| CHEMBL27508 |  |
IC50 | = | 1.0 | nM | 412.49 | CCCn1c(=O)c2c(nc(/C=C/c3ccc(OC)c(OC)c3)n2C)n(CCC)c1=O | Homo sapiens | CHEMBL640306 | assay format |
| CHEMBL5413330 |  |
IC50 | = | 1.1 | nM | 386.46 | COc1cccc2c1nc(N)n1nc(C3CC3c3ccc4c(c3)CCNC4)nc21 | Homo sapiens | CHEMBL5375925 | cell membrane format |
| CHEMBL5426841 |  |
IC50 | = | 1.3 | nM | 404.47 | COc1cccc2c1nc(N)n1nc([C@H]3C[C@H](c4ccc(C(C)(C)O)cn4)C3)nc21 | Homo sapiens | CHEMBL5375925 | cell membrane format |
| CHEMBL5426527 |  |
IC50 | = | 1.4 | nM | 417.52 | COc1cccc2c1nc(N)n1nc(C3CCC(c4ccc(C(C)(C)N)cn4)C3)nc21 | Homo sapiens | CHEMBL5375925 | cell membrane format |
| CHEMBL4857871 |  |
IC50 | = | 4.8 | nM | 339.36 | Nc1nc(NCCc2ccc(O)cc2)nc2nc(C3=CCCO3)nn12 | Homo sapiens | CHEMBL4807308 | cell-based format |
| CHEMBL3694769 |  |
IC50 | = | 5.6 | nM | 306.13 | Nc1nc(-n2cccn2)nc(-n2cccn2)c1Br | Homo sapiens | CHEMBL4807308 | cell-based format |
| CHEMBL4849795 |  |
IC50 | = | 9.2 | nM | 274.33 | Nc1nc(Cc2ccccc2)cn2c1nc1ccccc12 | Homo sapiens | CHEMBL4814786 | cell membrane format |
| CHEMBL4128926 |  |
IC50 | = | 9.2 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121466 | single protein format |
| CHEMBL2024116 |  |
IC50 | = | 10.0 | nM | 295.32 | Cc1cc(-c2nnc(N)nc2-c2ccc(F)cc2)cc(C)n1 | Homo sapiens | CHEMBL4701054 | single protein format |
| CHEMBL4855390 |  |
IC50 | = | 10.1 | nM | 339.2 | Nc1nc(-c2cccc(Br)c2)cn2c1nc1ccccc12 | Homo sapiens | CHEMBL4814786 | cell membrane format |
| CHEMBL4846301 |  |
IC50 | = | 10.1 | nM | 290.33 | COc1cccc(-c2cn3c(nc4ccccc43)c(N)n2)c1 | Homo sapiens | CHEMBL4814786 | cell membrane format |
| CHEMBL4846299 |  |
IC50 | = | 14.4 | nM | 274.33 | Cc1ccc(-c2cn3c(nc4ccccc43)c(N)n2)cc1 | Homo sapiens | CHEMBL4814786 | cell membrane format |
| CHEMBL124788 |  |
IC50 | = | 18.0 | nM | 326.79 | CCCCc1nc2[nH]cnc2c2nc(-c3ccccc3Cl)nn12 | Homo sapiens | CHEMBL640305 | cell-based format |
| CHEMBL330982 |  |
IC50 | = | 23.0 | nM | 312.34 | c1ccc(-c2nc3c4[nH]cnc4nc(-c4ccccc4)n3n2)cc1 | Homo sapiens | CHEMBL640305 | cell-based format |
| CHEMBL4857237 |  |
IC50 | = | 26.5 | nM | 328.3 | Nc1nc(-c2ccc(C(F)(F)F)cc2)cn2c1nc1ccccc12 | Homo sapiens | CHEMBL4814786 | cell membrane format |
| CHEMBL4862573 |  |
IC50 | = | 27.0 | nM | 326.31 | COc1cccc(-c2cn3c(nc4cc(F)c(F)cc43)c(N)n2)c1 | Homo sapiens | CHEMBL4814786 | cell membrane format |
| CHEMBL4872721 |  |
IC50 | = | 32.6 | nM | 250.26 | Nc1nc(-c2ccco2)cn2c1nc1ccccc12 | Homo sapiens | CHEMBL4814786 | cell membrane format |