P28907 | CD38_HUMAN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02267 | Rib_hydrolayse - ADP-ribosyl cyclase | 56~296 |
3D structures mapped by conservation among orthologs
[ Domain: "N-deoxyribosyltransferase" // Rib_hydrolayse ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5410644 |  |
IC50 | = | 0.3 | nM | 283.27 | O=C(Nc1cccc(F)c1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5401022 |  |
IC50 | = | 1.3 | nM | 317.71 | O=C(Nc1ccc(Cl)c(F)c1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5418653 |  |
IC50 | = | 1.3 | nM | 299.72 | O=C(Nc1cccc(Cl)c1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL3426065 |  |
IC50 | = | 1.4 | nM | 396.52 | CNC(=O)[C@H]1CC[C@H](Nc2cc(=O)[nH]c3c(C)cc(-c4cncs4)cc23)CC1 | Homo sapiens | CHEMBL3428359 | assay format |
| CHEMBL5426011 |  |
IC50 | = | 1.4 | nM | 333.27 | O=C(Nc1ccc(C(F)(F)F)cc1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5436403 |  |
IC50 | = | 1.4 | nM | 301.26 | O=C(Nc1cc(F)cc(F)c1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5434460 |  |
IC50 | = | 1.5 | nM | 290.29 | N#Cc1ccc(NC(=O)c2ccnc(-n3ccnc3)n2)cc1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5425216 |  |
IC50 | = | 1.5 | nM | 283.27 | O=C(Nc1ccc(F)cc1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5398114 |  |
IC50 | = | 1.5 | nM | 301.26 | O=C(Nc1ccc(F)c(F)c1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5440681 |  |
IC50 | = | 1.6 | nM | 299.72 | O=C(Nc1ccc(Cl)cc1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5427901 |  |
IC50 | = | 2.0 | nM | 266.26 | O=C(Nc1ccncc1)c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5440312 |  |
IC50 | = | 2.0 | nM | 279.3 | Cc1ccc(NC(=O)c2ccnc(-n3ccnc3)n2)cc1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL5405079 |  |
IC50 | = | 2.4 | nM | 279.3 | Cc1cccc(NC(=O)c2ccnc(-n3ccnc3)n2)c1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL3426064 |  |
IC50 | = | 3.4 | nM | 382.49 | CNC(=O)[C@H]1CC[C@H](Nc2cc(=O)[nH]c3ccc(-c4cncs4)cc23)CC1 | Homo sapiens | CHEMBL3428359 | assay format |
| CHEMBL5414411 |  |
IC50 | = | 3.8 | nM | 334.26 | O=C(Nc1ccncc1)c1cc(C(F)(F)F)nc(-n2ccnc2)n1 | Homo sapiens | CHEMBL5368228 | single protein format |
| CHEMBL3426037 |  |
IC50 | = | 3.8 | nM | 369.49 | CO[C@H]1CC[C@H](Nc2cc(=O)[nH]c3c(C)cc(-c4cncs4)cc23)CC1 | Homo sapiens | CHEMBL3428359 | assay format |
| CHEMBL3426033 |  |
IC50 | = | 3.9 | nM | 413.54 | COCCO[C@H]1CC[C@H](Nc2cc(=O)[nH]c3c(C)cc(-c4cncs4)cc23)CC1 | Homo sapiens | CHEMBL3428359 | assay format |
| CHEMBL4229241 |  |
IC50 | = | 4.0 | nM | 514.49 | NC(=O)c1cccc2c1NC(N1Cc3c(N)n[nH]c3C13CC3)=NC2NCc1c(F)cccc1C(F)(F)F | Homo sapiens | CHEMBL4222829 | assay format |
| CHEMBL5178786 |  |
IC50 | = | 4.0 | nM | 427.46 | COCCO[C@H]1CC[C@H](NC(=O)c2cc(-n3ccnc3)cc3c([N+](=O)[O-])c[nH]c23)CC1 | Homo sapiens | CHEMBL5148891 | single protein format |
| CHEMBL5076763 |  |
IC50 | = | 4.2 | nM | 425.49 | COCCO[C@H]1CC[C@H](NC(=O)c2cc(-c3cnn(C)c3)nc(-n3ccnc3)n2)CC1 | Homo sapiens | CHEMBL5032487 | single protein format |