P28838 | AMPL_HUMAN | Cytosol aminopeptidase (LAP3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00883 | Peptidase_M17 - Cytosol aminopeptidase family, catalytic domain | 197~508 | |
| PF02789 | Peptidase_M17_N - Cytosol aminopeptidase family, N-terminal domain | 37~169 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL79092 |  |
IC50 | = | 180.0 | nM | 477.59 | C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL708591 | single protein format |
| CHEMBL311875 |  |
IC50 | = | 300.0 | nM | 459.55 | C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL708591 | single protein format |
| CHEMBL29292 |  |
Ki | = | 0.6 | nM | 308.38 | CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL881814 | single protein format |
| CHEMBL254284 |  |
Ki | = | 45.0 | nM | 361.38 | N[C@@H](CCc1ccccc1)P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929612 | single protein format |
| CHEMBL4208547 |  |
Ki | = | 50.0 | nM | 247.15 | CC1(C)OB(C(N)Cc2ccccc2)OC1(C)C | Homo sapiens | CHEMBL4194821 | single protein format |
| CHEMBL88476 |  |
Ki | = | 60.0 | nM | 115.18 | CC(C)CC(N)C=O | Homo sapiens | CHEMBL881814 | single protein format |
| CHEMBL2153736 |  |
Ki | = | 65.0 | nM | 279.32 | CC(C)CC(CP(=O)(O)[C@@H](N)CC(C)C)C(=O)O | Homo sapiens | CHEMBL2155991 | single protein format |
| CHEMBL328319 |  |
Ki | = | 65.0 | nM | 279.32 | CC(C)CC(CP(=O)(O)C(N)CC(C)C)C(=O)O | Homo sapiens | CHEMBL881814 | single protein format |
| CHEMBL327844 |  |
Ki | = | 66.0 | nM | 361.38 | NC(CCc1ccccc1)P(=O)(O)CC(Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL881814 | single protein format |
| CHEMBL88808 |  |
Ki | = | 67.0 | nM | 377.38 | NC(CCc1ccccc1)P(=O)(O)CC(Cc1ccc(O)cc1)C(=O)O | Homo sapiens | CHEMBL881814 | single protein format |
| CHEMBL327182 |  |
Ki | = | 74.0 | nM | 327.36 | CC(C)CC(CP(=O)(O)C(N)CCc1ccccc1)C(=O)O | Homo sapiens | CHEMBL881814 | single protein format |
| CHEMBL284501 |  |
Ki | = | 76.0 | nM | 199.25 | COC(=O)/C=C\C(=O)[C@@H](N)CC(C)C | Homo sapiens | CHEMBL706550 | single protein format |
| CHEMBL1689155 |  |
Ki | = | 120.0 | nM | 274.36 | CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC(C)C)C(=O)O | Homo sapiens | CHEMBL706599 | single protein format |
| CHEMBL28650 |  |
Ki | = | 220.0 | nM | 474.56 | CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)C(C)C)C(C)C | Homo sapiens | CHEMBL706541 | single protein format |
| CHEMBL40422 |  |
Ki | = | 230.0 | nM | 167.15 | CC(C)C[C@H](N)P(=O)(O)O | Homo sapiens | CHEMBL706601 | single protein format |
| CHEMBL1093530 |  |
Ki | = | 230.0 | nM | 243.24 | CC(C)CC(N)P(=O)(O)Oc1ccccc1 | Homo sapiens | CHEMBL1115226 | single protein format |
| CHEMBL89318 |  |
Ki | = | 230.0 | nM | 167.14 | CC(C)CC(N)P(=O)(O)O | Homo sapiens | CHEMBL881814 | single protein format |
| CHEMBL252204 |  |
Ki | = | 271.0 | nM | 361.38 | N[C@@H](CCc1ccccc1)P(=O)(O)C[C@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929612 | single protein format |
| CHEMBL88179 |  |
Ki | = | 330.0 | nM | 223.21 | CC(C)CC(N)P(=O)(O)CCC(=O)O | Homo sapiens | CHEMBL881814 | single protein format |
| CHEMBL68979 |  |
Ki | = | 330.0 | nM | 438.47 | CC(C)C[C@H](/N=C(\S)[C@@H](O)[C@H](N)Cc1ccccc1)C(=O)O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL706596 | single protein format |