P28702 | RXRB_HUMAN | Retinoic acid receptor RXR-beta (RXRB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 336~512 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 204~272 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL705 |  |
IC50 | = | 12.0 | nM | 300.44 | CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL798189 | single protein format |
| CHEMBL424636 |  |
IC50 | = | 50.0 | nM | 390.57 | C/C(=C\c1ccc(C(=O)O)cc1)c1cc2c(cc1C(C)C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL798189 | single protein format |
| CHEMBL284937 |  |
IC50 | = | 50.0 | nM | 376.54 | CCc1cc2c(cc1/C(C)=C/c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL798189 | single protein format |
| CHEMBL38 |  |
Ki | = | 0.5 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL651296 | single protein format |
| CHEMBL111589 |  |
Ki | = | 2.0 | nM | 368.52 | COc1cc2c(cc1/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL804834 | single protein format |
| CHEMBL337393 |  |
Ki | = | 2.4 | nM | 462.48 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2cc(F)cc(F)c2)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL801226 | cell-based format |
| CHEMBL133915 |  |
Ki | = | 3.9 | nM | 444.49 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2ccc(F)cc2)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL801226 | cell-based format |
| CHEMBL130374 |  |
Ki | = | 3.9 | nM | 432.53 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2cccs2)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL801226 | cell-based format |
| CHEMBL41422 |  |
Ki | = | 4.0 | nM | 460.49 | C/C(=C(/F)C(=O)O)c1cc2cccc(-c3cc(C(C)C)cc(C(C)C)c3OCC(F)F)c2o1 | Homo sapiens | CHEMBL806017 | single protein format |
| CHEMBL92284 |  |
Ki | = | 4.0 | nM | 352.52 | CC(/C=C/C1(c2cc3c(cc2C)C(C)(C)CCC3(C)C)CC1)=C\C(=O)O | Homo sapiens | CHEMBL800751 | single protein format |
| CHEMBL42314 |  |
Ki | = | 4.0 | nM | 420.54 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OCC(F)F | Homo sapiens | CHEMBL801226 | cell-based format |
| CHEMBL162334 |  |
Ki | = | 5.0 | nM | 365.47 | Cc1cc2c(cc1/C(=N/O)c1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL806009 | single protein format |
| CHEMBL130231 |  |
Ki | = | 5.2 | nM | 466.58 | CCC(C)(C)c1cc(/C(C)=C(F)\C=C\C(C)=C\C(=O)O)c(OCC(F)F)c(C(C)(C)CC)c1 | Homo sapiens | CHEMBL801226 | cell-based format |
| CHEMBL1023 |  |
Ki | = | 5.9 | nM | 348.49 | C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL798320 | single protein format |
| CHEMBL348797 |  |
Ki | = | 6.0 | nM | 430.34 | CC1(C)CCC(C)(C)c2cc(/C(=N/O)c3ccc(C(=O)O)cc3)c(Br)cc21 | Homo sapiens | CHEMBL806009 | single protein format |
| CHEMBL93518 |  |
Ki | = | 7.0 | nM | 338.49 | CC(/C=C/C1(c2ccc3c(c2)C(C)(C)CCC3(C)C)CC1)=C\C(=O)O | Homo sapiens | CHEMBL800751 | single protein format |
| CHEMBL130232 |  |
Ki | = | 7.4 | nM | 444.49 | C/C(=C/C=C/C(C)=C/C(=O)O)c1cc(-c2cccc(F)c2)cc(C(C)C)c1OCC(F)F | Homo sapiens | CHEMBL801226 | cell-based format |
| CHEMBL423465 |  |
Ki | = | 8.0 | nM | 379.5 | CO/N=C(\c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C | Homo sapiens | CHEMBL806009 | single protein format |
| CHEMBL424269 |  |
Ki | = | 8.2 | nM | 460.48 | CCCCOc1c(/C(C)=C\C=C\C(C)=C\C(=O)O)cc(C(F)(F)C(F)(F)F)cc1C(C)C | Homo sapiens | CHEMBL801226 | cell-based format |
| CHEMBL133896 |  |
Ki | = | 8.5 | nM | 432.43 | CCOc1c(/C(C)=C\C=C\C(C)=C\C(=O)O)cc(C(F)(F)C(F)(F)F)cc1C(C)C | Homo sapiens | CHEMBL801226 | cell-based format |