P28566 | 5HT1E_HUMAN | 5-hydroxytryptamine receptor 1E (HTR1E)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 40~344 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL39 |  |
Ki | = | 4.0 | nM | 176.22 | NCCc1c[nH]c2ccc(O)cc12 | Homo sapiens | CHEMBL616848 | assay format |
| CHEMBL263881 |  |
Ki | = | 93.0 | nM | 323.44 | CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 | Homo sapiens | CHEMBL616716 | single protein format |
| CHEMBL3139682 |  |
Ki | < | 100.0 | nM | 325.84 | Nc1ccc2ccc(CCNCCc3cccc(Cl)c3)cc2n1 | Homo sapiens | CHEMBL4041190 | cell-based format |
| CHEMBL3039520 |  |
Ki | = | 126.87 | nM | 377.37 | CN1CCC(C(=O)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | Homo sapiens | CHEMBL5442218 | single protein format |
| CHEMBL138989 |  |
Ki | = | 140.0 | nM | 335.45 | C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | Homo sapiens | CHEMBL616716 | single protein format |
| CHEMBL5091373 |  |
Ki | = | 180.0 | nM | 312.24 | CNCCc1ccc(Cl)c(-c2ccccc2OC)c1.Cl | Homo sapiens | CHEMBL5039778 | single protein format |
| CHEMBL137781 |  |
Ki | = | 200.0 | nM | 335.45 | C[C@@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | Homo sapiens | CHEMBL616716 | single protein format |
| CHEMBL343755 |  |
Ki | = | 280.0 | nM | 335.45 | C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1 | Homo sapiens | CHEMBL616716 | single protein format |
| CHEMBL2138684 |  |
Ki | = | 310.74 | nM | 379.41 | CN[C@@H]1CCc2[nH]c3ccc(C(N)=O)cc3c2C1.O.O=C(O)CCC(=O)O | Homo sapiens | CHEMBL5442218 | single protein format |
| CHEMBL4163428 |  |
Ki | = | 403.0 | nM | 351.45 | CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1 | Homo sapiens | CHEMBL4153377 | cell-based format |
| CHEMBL2391541 |  |
Ki | = | 413.0 | nM | 270.38 | C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12 | Homo sapiens | CHEMBL2393677 | cell-based format |
| CHEMBL2105760 |  |
Ki | = | 477.97 | nM | 433.58 | O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1 | Homo sapiens | CHEMBL5442218 | single protein format |
| CHEMBL267615 |  |
Ki | = | 520.0 | nM | 246.35 | CCc1[nH]c2ccc(OC)cc2c1CCN(C)C | Homo sapiens | CHEMBL872911 | single protein format |
| CHEMBL267777 |  |
Ki | = | 556.42 | nM | 477.58 | Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL5442218 | single protein format |
| CHEMBL103479 |  |
Ki | = | 660.0 | nM | 352.41 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | Homo sapiens | CHEMBL616850 | assay format |
| CHEMBL5207529 |  |
Ki | = | 666.0 | nM | 409.31 | COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC.Cl | Homo sapiens | CHEMBL5135866 | single protein format |
| CHEMBL5077293 |  |
Ki | = | 770.0 | nM | 287.79 | COc1ccccc1-c1cc(C2CCNC2)ccc1Cl | Homo sapiens | CHEMBL5039778 | single protein format |
| CHEMBL105261 |  |
Ki | = | 770.0 | nM | 286.38 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | Homo sapiens | CHEMBL616850 | assay format |
| CHEMBL4209274 |  |
Ki | = | 793.0 | nM | 231.27 | Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | Homo sapiens | CHEMBL4199352 | cell-based format |
| CHEMBL4210782 |  |
Ki | = | 890.0 | nM | 227.31 | Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1 | Homo sapiens | CHEMBL4199352 | cell-based format |