P28472 | GBRB3_HUMAN | Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 39~242 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 250~468 |
3D structures mapped by conservation among orthologs
[ Domain: "Nicotinic receptor ligand binding domain-like" // Neur_chan_LBD ]
[ Domain: "Neurotransmitter-gated ion-channel transmembrane pore" // Neur_chan_memb ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1890408 |  |
IC50 | = | 0.47 | nM | 406.93 | O=S1OC[C@@H]2[C@H](CO1)[C@@]1(Cl)C(Cl)=C(Cl)[C@]2(Cl)C1(Cl)Cl | Homo sapiens | CHEMBL3073472 | single protein format |
| CHEMBL15891 |  |
IC50 | = | 0.9 | nM | 290.83 | Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl | Homo sapiens | CHEMBL3073472 | single protein format |
| CHEMBL101326 |  |
IC50 | = | 28.0 | nM | 437.15 | N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1[S+]([O-])C(F)(F)F | Homo sapiens | CHEMBL683058 | single protein format |
| CHEMBL329306 |  |
IC50 | = | 28.0 | nM | 389.09 | FC(F)(F)c1cc(Cl)c(-n2cc(C3(C(F)(F)F)N=N3)cn2)c(Cl)c1 | Homo sapiens | CHEMBL683058 | single protein format |
| CHEMBL235623 |  |
Ki | = | 0.659 | nM | 372.61 | CCCc1nnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1CCl | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL236471 |  |
Ki | = | 1.94 | nM | 338.16 | CCCc1nnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1C | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL395136 |  |
Ki | = | 2.53 | nM | 354.16 | CCCc1nnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1CO | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL392036 |  |
Ki | = | 4.27 | nM | 338.16 | CCc1nnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1CC | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL392035 |  |
Ki | = | 7.08 | nM | 324.13 | CCc1nnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1C | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL236671 |  |
Ki | = | 8.07 | nM | 352.19 | CCCc1nnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1CC | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL396305 |  |
Ki | = | 13.6 | nM | 427.06 | CCCc1nnn(-c2c(Br)cc(C(F)(F)F)cc2Br)c1C | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL235405 |  |
Ki | = | 47.2 | nM | 352.19 | CCCc1c(CC)nnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL395137 |  |
Ki | = | 66.7 | nM | 372.61 | CCCc1c(CCl)nnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL236470 |  |
Ki | = | 70.1 | nM | 324.13 | CCc1c(C)nnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL235406 |  |
Ki | = | 128.0 | nM | 366.21 | CCCc1nnn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1CCC | Homo sapiens | CHEMBL898326 | cell-based format |
| CHEMBL428023 |  |
Ki | = | 539.0 | nM | 338.16 | CCCc1c(C)nnn1-c1c(Cl)cc(C(F)(F)F)cc1Cl | Homo sapiens | CHEMBL898326 | cell-based format |