P28336 | NMBR_HUMAN | Neuromedin-B receptor (NMBR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 60~322 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL405908 |  |
IC50 | = | 0.66 | nM | 584.68 | COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)nc1 | Homo sapiens | CHEMBL649929 | tissue-based format |
| CHEMBL563374 |  |
IC50 | = | 96.0 | nM | 426.48 | Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL559860 |  |
IC50 | = | 150.0 | nM | 440.99 | CCCCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL563564 |  |
IC50 | = | 170.0 | nM | 398.91 | Cc1ccc2c(c1)N(C)C(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL538178 |  |
IC50 | = | 180.0 | nM | 412.94 | CCN1c2cc(C)ccc2NC2=C(C(=O)CC(C)(C)C2)C1c1c(F)cccc1Cl | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL554477 |  |
IC50 | = | 200.0 | nM | 378.54 | CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC(C)(C)C2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL562834 |  |
IC50 | = | 240.0 | nM | 392.93 | Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL560655 |  |
IC50 | = | 250.0 | nM | 404.58 | CSc1ccccc1C1Nc2cc(C)ccc2NC2=C1C(=O)CC1(CCCC1)C2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL563531 |  |
IC50 | = | 250.0 | nM | 400.44 | Cc1ccc2c(c1)NC(c1ccccc1C(F)(F)F)C1=C(CC(C)(C)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL564151 |  |
IC50 | = | 280.0 | nM | 366.89 | Cc1ccc2c(c1)NC(c1ccccc1Cl)C1=C(CC(C)(C)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL562376 |  |
IC50 | = | 280.0 | nM | 410.92 | Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC3(CCCC3)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL552189 |  |
IC50 | = | 300.0 | nM | 384.88 | Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)(C)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL86828 |  |
IC50 | = | 350.0 | nM | 593.82 | CC(C)c1cccc(C(C)C)c1NC(=O)N[C@@](C)(Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccn2)CCCCC1 | Homo sapiens | CHEMBL752221 | cell-based format |
| CHEMBL564278 |  |
IC50 | = | 370.0 | nM | 438.85 | CC1(C)CC(=O)C2=C(C1)Nc1ccc(C(F)(F)F)cc1NC2c1c(F)cccc1Cl | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL550558 |  |
IC50 | = | 450.0 | nM | 370.86 | Cc1ccc2c(c1)NC(c1c(F)cccc1Cl)C1=C(CC(C)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL550567 |  |
IC50 | = | 540.0 | nM | 444.47 | Cc1ccc2c(c1)NC(c1c(F)cccc1C(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL561979 |  |
IC50 | = | 550.0 | nM | 377.44 | Cc1ccc2c(c1)NC(c1ccccc1[N+](=O)[O-])C1=C(CC(C)(C)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL103439 |  |
IC50 | = | 620.0 | nM | 580.69 | Cc1cc([N+](=O)[O-])ccc1NC(=O)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 | Homo sapiens | CHEMBL752221 | cell-based format |
| CHEMBL557707 |  |
IC50 | = | 640.0 | nM | 458.55 | Cc1ccc2c(c1)NC(c1ccccc1SC(F)(F)F)C1=C(CC3(CCCC3)CC1=O)N2 | Homo sapiens | CHEMBL1057866 | cell-based format |
| CHEMBL103440 |  |
IC50 | = | 800.0 | nM | 566.66 | O=C(Nc1ccc([N+](=O)[O-])cc1)NC1(C(=O)NCC2(c3ccccn3)CCCCC2)CCc2[nH]c3ccccc3c2C1 | Homo sapiens | CHEMBL752221 | cell-based format |