P28222 | 5HT1B_HUMAN | 5-hydroxytryptamine receptor 1B (HTR1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 67~369 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_2 ]
[ Domain: "Cytochromes" // Cytochrom_B562_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL194837 |  |
IC50 | = | 0.2 | nM | 448.35 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | Homo sapiens | CHEMBL881488 | single protein format |
| CHEMBL159396 |  |
IC50 | = | 0.5 | nM | 388.48 | c1cnc(N2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | Homo sapiens | CHEMBL616642 | cell-based format |
| CHEMBL296161 |  |
IC50 | = | 1.3 | nM | 255.32 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | Homo sapiens | CHEMBL616642 | cell-based format |
| CHEMBL161176 |  |
IC50 | = | 2.4 | nM | 457.58 | CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | Homo sapiens | CHEMBL616642 | cell-based format |
| CHEMBL348304 |  |
IC50 | = | 2.7 | nM | 401.51 | c1ccc(COC[C@@H]2CCCN2CCc2c[nH]c3ccc(-n4cnnc4)cc23)cc1 | Homo sapiens | CHEMBL616641 | cell-based format |
| CHEMBL65824 |  |
IC50 | = | 3.1 | nM | 435.52 | Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | Homo sapiens | CHEMBL616643 | cell-based format |
| CHEMBL358072 |  |
IC50 | = | 3.3 | nM | 415.55 | c1ccc(NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | Homo sapiens | CHEMBL616639 | cell-based format |
| CHEMBL161045 |  |
IC50 | = | 4.4 | nM | 267.34 | c1cc2[nH]cc(CCN3CCC3)c2cc1-n1cnnc1 | Homo sapiens | CHEMBL616641 | cell-based format |
| CHEMBL39 |  |
IC50 | = | 5.0 | nM | 176.22 | NCCc1c[nH]c2ccc(O)cc12 | Homo sapiens | CHEMBL616807 | single protein format |
| CHEMBL65765 |  |
IC50 | = | 5.3 | nM | 435.52 | Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | Homo sapiens | CHEMBL616643 | cell-based format |
| CHEMBL147148 |  |
IC50 | = | 6.2 | nM | 471.61 | CN(CC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)C(=O)Nc1ccccc1 | Homo sapiens | CHEMBL616639 | cell-based format |
| CHEMBL162930 |  |
IC50 | = | 7.4 | nM | 311.39 | c1cc2[nH]cc(CCCN3CCOCC3)c2cc1-n1cnnc1 | Homo sapiens | CHEMBL616642 | cell-based format |
| CHEMBL147940 |  |
IC50 | = | 8.9 | nM | 485.64 | CC(=O)Nc1ccc(CNCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | Homo sapiens | CHEMBL616639 | cell-based format |
| CHEMBL146338 |  |
IC50 | = | 8.9 | nM | 499.66 | CC(=O)Nc1ccc([C@@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | Homo sapiens | CHEMBL616639 | cell-based format |
| CHEMBL146483 |  |
IC50 | = | 9.3 | nM | 499.66 | CC(=O)Nc1ccc([C@H](C)NCC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | Homo sapiens | CHEMBL616639 | cell-based format |
| CHEMBL163386 |  |
IC50 | = | 9.5 | nM | 430.56 | OCC(c1ccccc1)N1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | Homo sapiens | CHEMBL616642 | cell-based format |
| CHEMBL357634 |  |
IC50 | = | 10.0 | nM | 478.62 | CN(C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)S(=O)(=O)c1ccccc1 | Homo sapiens | CHEMBL616639 | cell-based format |
| CHEMBL128 |  |
IC50 | = | 11.0 | nM | 295.41 | CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1 | Homo sapiens | CHEMBL616642 | cell-based format |
| CHEMBL423599 |  |
IC50 | = | 11.0 | nM | 442.57 | CC(=O)N(Cc1ccccc1)C[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1 | Homo sapiens | CHEMBL616641 | cell-based format |
| CHEMBL65367 |  |
IC50 | = | 11.0 | nM | 400.53 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | Homo sapiens | CHEMBL616642 | cell-based format |