P28221 | 5HT1D_HUMAN | 5-hydroxytryptamine receptor 1D (HTR1D)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 56~356 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL65824 |  |
IC50 | = | 0.1 | nM | 435.52 | Fc1ccccc1CC1(F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | Homo sapiens | CHEMBL616912 | cell-based format |
| CHEMBL161723 |  |
IC50 | = | 0.1 | nM | 418.52 | Fc1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | Homo sapiens | CHEMBL616911 | cell-based format |
| CHEMBL112507 |  |
IC50 | = | 0.1 | nM | 415.54 | OC1(Cc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | Homo sapiens | CHEMBL616901 | cell-based format |
| CHEMBL65367 |  |
IC50 | = | 0.2 | nM | 400.53 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | Homo sapiens | CHEMBL616910 | cell-based format |
| CHEMBL161176 |  |
IC50 | = | 0.2 | nM | 457.58 | CC(=O)Nc1cccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | Homo sapiens | CHEMBL616911 | cell-based format |
| CHEMBL296161 |  |
IC50 | = | 0.3 | nM | 255.32 | CN(C)CCc1c[nH]c2ccc(-n3cnnc3)cc12 | Homo sapiens | CHEMBL616909 | cell-based format |
| CHEMBL63167 |  |
IC50 | = | 0.3 | nM | 485.53 | FC1(Cc2ccccc2C(F)(F)F)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | Homo sapiens | CHEMBL616912 | cell-based format |
| CHEMBL160070 |  |
IC50 | = | 0.3 | nM | 446.6 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(C[C@H]4COC(=O)N4)cc23)C1)c1ccccc1 | Homo sapiens | CHEMBL616908 | cell-based format |
| CHEMBL422366 |  |
IC50 | = | 0.3 | nM | 401.52 | c1cncc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | Homo sapiens | CHEMBL616911 | cell-based format |
| CHEMBL159483 |  |
IC50 | = | 0.35 | nM | 432.57 | O=C1N[C@@H](Cc2ccc3[nH]cc(CCN4CC[C@@H](CNCc5ccccc5)C4)c3c2)CO1 | Homo sapiens | CHEMBL616908 | cell-based format |
| CHEMBL294547 |  |
IC50 | = | 0.35 | nM | 399.54 | c1ccc(CC2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)cc1 | Homo sapiens | CHEMBL616910 | cell-based format |
| CHEMBL331970 |  |
IC50 | = | 0.35 | nM | 428.58 | C[C@@H](NC1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1)c1ccccc1 | Homo sapiens | CHEMBL616904 | cell-based format |
| CHEMBL163573 |  |
IC50 | = | 0.4 | nM | 401.52 | c1ccc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)nc1 | Homo sapiens | CHEMBL616911 | cell-based format |
| CHEMBL162805 |  |
IC50 | = | 0.4 | nM | 390.49 | c1coc(CN2CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | Homo sapiens | CHEMBL616911 | cell-based format |
| CHEMBL65765 |  |
IC50 | = | 0.4 | nM | 435.52 | Fc1cccc(CC2(F)CCN(CCCc3c[nH]c4ccc(-n5cnnc5)cc34)CC2)c1 | Homo sapiens | CHEMBL616912 | cell-based format |
| CHEMBL326125 |  |
IC50 | = | 0.45 | nM | 444.58 | OC1(CNCc2ccccc2)CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | Homo sapiens | CHEMBL616901 | cell-based format |
| CHEMBL349185 |  |
IC50 | = | 0.45 | nM | 390.49 | c1cc(CNC[C@@H]2CCN(CCc3c[nH]c4ccc(-n5cnnc5)cc34)C2)co1 | Homo sapiens | CHEMBL616908 | cell-based format |
| CHEMBL159759 |  |
IC50 | = | 0.45 | nM | 414.56 | C[C@H](NC[C@@H]1CCN(CCc2c[nH]c3ccc(-n4cnnc4)cc23)C1)c1ccccc1 | Homo sapiens | CHEMBL616908 | cell-based format |
| CHEMBL116031 |  |
IC50 | = | 0.5 | nM | 432.55 | Fc1ccccc1CCN1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | Homo sapiens | CHEMBL616911 | cell-based format |
| CHEMBL148233 |  |
IC50 | = | 0.5 | nM | 406.58 | CC(C)=CCN(C)C1CCN(CCCc2c[nH]c3ccc(-n4cnnc4)cc23)CC1 | Homo sapiens | CHEMBL616907 | cell-based format |