P28074 | PSB5_HUMAN | Proteasome subunit beta type-5 (PSMB5)

Pfam Domain Table

AccessionDomainRangeColor
PF00227Proteasome - Proteasome subunit56~238

3D structures mapped by conservation among orthologs

[ Domain: "Proteasome subunits" // Proteasome ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4089402 IC50 = 0.0002 nM 437.35 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)N1CCc2ccccc2C1)B(O)O Homo sapiens CHEMBL4042169 cell-based format
CHEMBL3347481 IC50 = 0.08 nM 547.47 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](CC(C)C)NC(=O)c1cnccn1)B(O)O Homo sapiens CHEMBL3391115 single protein format
CHEMBL4070336 IC50 = 0.3 nM 487.41 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1cccc(-c2ccccc2)c1)B(O)O Homo sapiens CHEMBL4042169 cell-based format
CHEMBL3347642 IC50 = 0.39 nM 547.42 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O Homo sapiens CHEMBL3391115 single protein format
CHEMBL3347640 IC50 = 0.42 nM 581.48 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)c1cnccn1)B(O)O Homo sapiens CHEMBL3391115 single protein format
CHEMBL3347626 IC50 = 0.55 nM 531.42 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O Homo sapiens CHEMBL3391115 single protein format
CHEMBL4297468 IC50 = 0.688 nM 586.69 COc1ccc([C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@@]2(C)CO2)cc1 Homo sapiens CHEMBL4403375 single protein format
CHEMBL3793848 IC50 = 0.76 nM 570.58 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2c1CCCC2)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1 Homo sapiens CHEMBL3796231 single protein format
CHEMBL3786398 IC50 = 1.02 nM 454.35 CC(C)C[C@@H](NC(=O)CC(NC(=O)[C@H]1CCCc2ccccc21)c1cccc(F)c1)B(O)O Homo sapiens CHEMBL3789477 single protein format
CHEMBL3794168 IC50 = 1.12 nM 570.58 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc21)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1 Homo sapiens CHEMBL3796231 single protein format
CHEMBL3793581 IC50 = 1.15 nM 536.57 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)c1cccc2c1CCCC2)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1 Homo sapiens CHEMBL3796231 single protein format
CHEMBL499361 IC50 = 1.2 nM 436.36 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc21)B(O)O Homo sapiens CHEMBL3789477 single protein format
CHEMBL4749207 IC50 = 1.4 nM 412.3 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(O)cc1)B(O)O Homo sapiens CHEMBL4682117 single protein format
CHEMBL3793242 IC50 = 1.46 nM 570.58 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1CCc2ccccc2C1)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1 Homo sapiens CHEMBL3796231 single protein format
CHEMBL499504 IC50 = 1.6 nM 436.36 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc2c1CCCC2)B(O)O Homo sapiens CHEMBL3789477 single protein format
CHEMBL3792511 IC50 = 1.92 nM 570.58 CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2ccccc21)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1 Homo sapiens CHEMBL3796231 single protein format
CHEMBL606394 IC50 = 1.92 nM 518.47 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B1OC2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1 Homo sapiens CHEMBL3796231 single protein format
CHEMBL4249022 IC50 = 1.98 nM 390.33 CCCCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)B(O)O Homo sapiens CHEMBL4233071 single protein format
CHEMBL4068221 IC50 = 2.0 nM 425.34 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)N(C)Cc1ccccc1)B(O)O Homo sapiens CHEMBL4042169 cell-based format
CHEMBL4100727 IC50 = 2.0 nM 447.29 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccc(F)c(F)c1)B(O)O Homo sapiens CHEMBL4042169 cell-based format