P27987 | IP3KB_HUMAN | Inositol-trisphosphate 3-kinase B (ITPKB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03770 | IPK - Inositol polyphosphate kinase | 726~936 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3716876 |  |
IC50 | < | 500.0 | nM | 472.43 | O=c1[nH]c(=O)c2cc(-c3n[nH]cc3CN3CCN(c4ccc(C(F)(F)F)cn4)CC3)ccc2o1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3719072 |  |
IC50 | < | 500.0 | nM | 471.49 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)N3)CCN1c1ccc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3716203 |  |
IC50 | < | 500.0 | nM | 484.48 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)C(=O)NC(=O)C3)CCN1c1ccc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3716969 |  |
IC50 | < | 500.0 | nM | 429.48 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1c1cc(C#N)ccn1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3719170 |  |
IC50 | < | 500.0 | nM | 473.46 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1c1nccc(C(F)(F)F)n1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3718179 |  |
IC50 | < | 500.0 | nM | 418.5 | Cc1ccc(N2CCN(Cc3c[nH]nc3-c3ccc4c(c3)CNC(=O)O4)C[C@H]2C)nc1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3714983 |  |
IC50 | < | 500.0 | nM | 472.47 | C[C@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1c1ccc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3719189 |  |
IC50 | < | 500.0 | nM | 409.53 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1C1CCCCC1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3716814 |  |
IC50 | < | 500.0 | nM | 473.46 | C[C@@H]1CN(Cc2n[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1c1ccc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3719050 |  |
IC50 | < | 500.0 | nM | 471.49 | O=C1NCc2cc(-c3n[nH]cc3CN3CCCN(c4ccc(C(F)(F)F)cn4)CC3)ccc2N1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3715760 |  |
IC50 | < | 500.0 | nM | 500.53 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)C(C)(C)NC(=O)O3)CCN1c1ccc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3716095 |  |
IC50 | < | 500.0 | nM | 429.48 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1c1ccc(C#N)cn1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3718093 |  |
IC50 | < | 500.0 | nM | 438.92 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1c1ccc(Cl)cn1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3718704 |  |
IC50 | < | 500.0 | nM | 502.45 | O=C1NCc2cc(-c3n[nH]cc3CN3CCN(c4ccc(C(F)(F)F)cn4)C[C@H]3C(=O)O)ccc2O1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3715999 |  |
IC50 | < | 500.0 | nM | 488.47 | O=C1NCc2cc(-c3n[nH]cc3CN3CCN(c4ccc(C(F)(F)F)cn4)C[C@H]3CO)ccc2O1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3715575 |  |
IC50 | < | 500.0 | nM | 490.46 | O=C1NCc2cc(-c3n[nH]cc3CN3CCN(c4ccc(C(F)(F)F)cn4)C[C@H]3CF)ccc2O1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3718520 |  |
IC50 | < | 500.0 | nM | 471.48 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3715847 |  |
IC50 | < | 500.0 | nM | 435.5 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1Cc1ccccc1F | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3717156 |  |
IC50 | < | 500.0 | nM | 437.93 | C[C@@H]1CN(Cc2c[nH]nc2-c2ccc3c(c2)CNC(=O)O3)CCN1c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3721068 | cell-based format |
| CHEMBL3717784 |  |
IC50 | < | 500.0 | nM | 484.48 | O=C1NCc2cc(-c3n[nH]cc3CN3CCN(c4ccc(C(F)(F)F)cn4)C4(CC4)C3)ccc2O1 | Homo sapiens | CHEMBL3721068 | cell-based format |