P27986 | P85A_HUMAN | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 333~408 | |
| PF00017 | SH2 - SH2 domain | 624~698 | |
| PF00620 | RhoGAP - RhoGAP domain | 129~274 | |
| PF16454 | PI3K_P85_iSH2 - Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain | 431~599 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Domain: "GTPase activation domain, GAP" // RhoGAP ]
[ Domain: "Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain" // PI3K_P85_iSH2 ]
[ Domain: "SH2" // SH2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL127907 |  |
IC50 | = | 2.0 | nM | 297.31 | COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC | Homo sapiens | CHEMBL936779 | single protein format |
| CHEMBL5287428 |  |
IC50 | = | 15.1 | nM | 475.56 | CN(c1nc(-c2cnc(N)nc2)nc(N2CCOCC2)n1)C1CCN(C(=O)c2ccccc2)CC1 | Homo sapiens | CHEMBL5241205 | single protein format |
| CHEMBL3981126 |  |
IC50 | = | 103.0 | nM | 549.61 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3953184 |  |
IC50 | = | 159.0 | nM | 552.61 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cn(C)cn4)c(F)c3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3945169 |  |
IC50 | = | 174.0 | nM | 563.63 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccnc(C)c4)c(F)c3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3922023 |  |
IC50 | = | 199.0 | nM | 533.98 | C#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc43)n(Cc3ccccc3Cl)c(=O)c12 | Homo sapiens | CHEMBL3888355 | single protein format |
| CHEMBL3982586 |  |
IC50 | = | 213.0 | nM | 548.62 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3972628 |  |
IC50 | = | 321.0 | nM | 563.63 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3947476 |  |
IC50 | = | 372.0 | nM | 531.62 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccccn4)cc3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3894827 |  |
IC50 | = | 468.0 | nM | 596.63 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cccc(OC(F)F)c4)cc3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3943611 |  |
IC50 | = | 472.0 | nM | 529.6 | CN1CC(C)(C)Oc2nc(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3908330 |  |
IC50 | = | 547.0 | nM | 486.55 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3892705 |  |
IC50 | = | 561.0 | nM | 539.57 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3975008 |  |
IC50 | = | 570.0 | nM | 566.61 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3903818 |  |
IC50 | = | 598.0 | nM | 579.63 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)c(F)c3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3958463 |  |
IC50 | = | 604.0 | nM | 551.6 | COCCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3902079 |  |
IC50 | = | 640.0 | nM | 549.61 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3F)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3957262 |  |
IC50 | = | 813.0 | nM | 564.65 | COCCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cnn(C)c4)cc3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3913302 |  |
IC50 | = | 824.0 | nM | 554.58 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4nnc(C)o4)c(F)c3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |
| CHEMBL3965674 |  |
IC50 | = | 991.0 | nM | 578.65 | CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cc(OC)ccc4F)cc3)c2C1=O | Homo sapiens | CHEMBL3887224 | single protein format |