P27707 | DCK_HUMAN | Deoxycytidine kinase (DCK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01712 | dNK - Deoxynucleoside kinase | 24~257 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // dNK ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1081002 |  |
IC50 | = | 0.7 | nM | 407.41 | N#Cc1ccccc1Oc1ncnc(N2CCC(Oc3nccc(N)n3)CC2)c1F | Homo sapiens | CHEMBL1101183 | single protein format |
| CHEMBL1081903 |  |
IC50 | = | 1.0 | nM | 455.43 | COc1ccc(C#N)cc1Oc1ncnc(N2CCC(Oc3ncc(F)c(N)n3)CC2)c1F | Homo sapiens | CHEMBL1101183 | single protein format |
| CHEMBL1080093 |  |
IC50 | = | 1.0 | nM | 425.4 | N#Cc1ccccc1Oc1ncnc(N2CCC(Oc3ncc(F)c(N)n3)CC2)c1F | Homo sapiens | CHEMBL1101183 | single protein format |
| CHEMBL2426563 |  |
IC50 | = | 1.07 | nM | 435.55 | CCCc1sc(-c2ccc(F)c(OCCO)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL2426570 |  |
IC50 | = | 1.15 | nM | 447.59 | CCCc1sc(-c2ccc(OC)c(OCCO)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL3358096 |  |
IC50 | = | 1.25 | nM | 549.72 | CCOc1cc(-c2nc([C@@H](C)Sc3nc(N)cc(N)n3)c(C)s2)ccc1OCCOCCOCCOC | Homo sapiens | CHEMBL3381706 | cell-based format |
| CHEMBL2426573 |  |
IC50 | = | 1.44 | nM | 475.64 | CCCc1sc(-c2ccc(OC)c(OCC(C)(C)O)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL2426569 |  |
IC50 | = | 1.55 | nM | 461.61 | CCCc1sc(-c2ccc(OC)c(OCCCO)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL1080444 |  |
IC50 | = | 1.7 | nM | 449.51 | Nc1nc(=O)n([C@H]2CC[C@H](NC(=O)c3cc(-c4cc5ccccc5s4)ccn3)C2)cc1F | Homo sapiens | CHEMBL1101518 | assay format |
| CHEMBL1081904 |  |
IC50 | = | 2.0 | nM | 455.43 | COc1ccc(Oc2ncnc(N3CCC(Oc4ncc(F)c(N)n4)CC3)c2F)c(C#N)c1 | Homo sapiens | CHEMBL1101183 | single protein format |
| CHEMBL2426562 |  |
IC50 | = | 2.45 | nM | 417.56 | CCCc1sc(-c2cccc(OCCO)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL2426567 |  |
IC50 | = | 2.59 | nM | 477.61 | CCCc1sc(-c2ccc(OCCO)c(OCCO)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL2426564 |  |
IC50 | = | 2.83 | nM | 435.55 | CCCc1sc(-c2cc(F)cc(OCCO)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL2426572 |  |
IC50 | = | 2.85 | nM | 461.61 | CCCc1sc(-c2ccc(OC)c(OCC(C)O)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL2426571 |  |
IC50 | = | 2.9 | nM | 432.57 | CCCc1sc(-c2ccc(OC)c(OCCO)c2)nc1CSc1nccc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |
| CHEMBL1079906 |  |
IC50 | = | 3.0 | nM | 407.41 | N#Cc1ccccc1Oc1cc(N2CCC(Oc3ncc(F)c(N)n3)CC2)ncn1 | Homo sapiens | CHEMBL1101183 | single protein format |
| CHEMBL1079768 |  |
IC50 | = | 3.0 | nM | 450.54 | Nc1nc(OCCC2CCN(c3cc(-c4cc5ccccc5s4)ncn3)CC2)ncc1F | Homo sapiens | CHEMBL1101183 | single protein format |
| CHEMBL1080443 |  |
IC50 | = | 3.0 | nM | 416.84 | Nc1nc(OC2CCN(c3cc(Oc4ccccc4Cl)ncn3)CC2)ncc1F | Homo sapiens | CHEMBL1101183 | single protein format |
| CHEMBL1080636 |  |
IC50 | = | 3.0 | nM | 437.44 | COc1ccc(Oc2cc(N3CCC(Oc4ncc(F)c(N)n4)CC3)ncn2)c(C#N)c1 | Homo sapiens | CHEMBL1101183 | single protein format |
| CHEMBL2426558 |  |
IC50 | = | 3.0 | nM | 449.58 | CCCc1sc(-c2ccc(OC)c(OCCF)c2)nc1CSc1nc(N)cc(N)n1 | Homo sapiens | CHEMBL2429676 | cell-based format |