P27695 | APEX1_HUMAN | DNA-(apurinic or apyrimidinic site) endonuclease (APEX1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03372 | Exo_endo_phos - Endonuclease/Exonuclease/phosphatase family | 65~309 |
3D structures mapped by conservation among orthologs
[ Domain: "DNase I-like" // Exo_endo_phos ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL275938 |  |
IC50 | = | 55.0 | nM | 422.35 | O=C(O)C1=CC(=C(c2ccc(O)c(C(=O)O)c2)c2ccc(O)c(C(=O)O)c2)C=CC1=O | Homo sapiens | CHEMBL4185154 | single protein format |
| CHEMBL4210534 |  |
IC50 | = | 55.0 | nM | 512.7 | c1cc2ccc3cc2cc1CNCCOCCNCc1ccc2ccc(cc2c1)CNCCOCCNC3 | Homo sapiens | CHEMBL4185143 | single protein format |
| CHEMBL4205402 |  |
IC50 | = | 57.0 | nM | 510.73 | c1cc2ccc3cc2cc1CNCCNCCNCc1ccc2ccc(cc2c1)CNCCNCCNC3 | Homo sapiens | CHEMBL4185143 | single protein format |
| CHEMBL22077 |  |
IC50 | = | 80.0 | nM | 356.49 | CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 | Homo sapiens | CHEMBL4185157 | assay format |
| CHEMBL109037 |  |
IC50 | = | 110.0 | nM | 213.19 | NC(Cc1cc(O)c(O)cc1O)C(=O)O | Homo sapiens | CHEMBL3389217 | single protein format |
| CHEMBL4205950 |  |
IC50 | = | 250.0 | nM | 498.47 | CC(=O)Nc1ccc(/C=C/c2ccc(N=C=S)c(S(=O)(=O)[O-])c2)c(S(=O)(=O)[O-])c1.[Na+].[Na+] | Homo sapiens | CHEMBL4185152 | single protein format |
| CHEMBL56393 |  |
IC50 | = | 280.0 | nM | 297.27 | N#C/C(=C\c1ccc(O)c(O)c1)C(=O)c1ccc(O)c(O)c1 | Homo sapiens | CHEMBL4185153 | single protein format |
| CHEMBL164 |  |
IC50 | = | 320.0 | nM | 318.24 | O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL3389217 | single protein format |
| CHEMBL1601846 |  |
IC50 | = | 400.0 | nM | 278.17 | O=c1oc2c(cc1O)oc(=O)c1cc(O)c(O)c(O)c12 | Homo sapiens | CHEMBL4185149 | single protein format |
| CHEMBL1346456 |  |
IC50 | = | 400.0 | nM | 300.31 | COc1cc2c(ccc3cc(OC)c(OC)c(O)c32)cc1O | Homo sapiens | CHEMBL4185149 | single protein format |
| CHEMBL1256623 |  |
IC50 | = | 500.0 | nM | 168.15 | CN(N=O)c1ccc(O)c(O)c1 | Homo sapiens | CHEMBL4185153 | single protein format |
| CHEMBL4211672 |  |
IC50 | = | 800.0 | nM | 400.97 | CC(C)(C)c1ccc(OC(=O)c2sc3ccccc3c2Cl)c(C(C)(C)C)c1 | Homo sapiens | CHEMBL4185144 | cell-based format |
| CHEMBL4203747 |  |
IC50 | = | 900.0 | nM | 429.35 | Cc1sc(Nc2cc(Cl)cc(Cl)c2)nc1-c1ccc(-c2ccccc2F)cc1 | Homo sapiens | CHEMBL4185144 | cell-based format |
| CHEMBL568994 |  |
IC50 | = | 1000.0 | nM | 276.67 | C/C(=C\C1=C(Cl)C(=O)c2ccccc2C1=O)C(=O)O | Homo sapiens | CHEMBL1043577 | cell-based format |
| CHEMBL399043 |  |
IC50 | = | 1000.0 | nM | 210.3 | C=C/C(C)=C/[C@@]1(C)SC(=O)C(C)=C1O | Homo sapiens | CHEMBL4185153 | single protein format |
| CHEMBL1706858 |  |
IC50 | = | 1000.0 | nM | 315.42 | CC(=O)Nc1sc2c(c1-c1nc3ccccc3s1)CNC2 | Homo sapiens | CHEMBL2061059 | single protein format |
| CHEMBL570294 |  |
IC50 | = | 1000.0 | nM | 319.74 | C/C(=C\C1=C(Cl)C(=O)c2ccccc2C1=O)C(=O)NCCO | Homo sapiens | CHEMBL1043577 | cell-based format |
| CHEMBL570293 |  |
IC50 | = | 1000.0 | nM | 365.18 | COCC/C(=C\C1=C(Br)C(=O)c2ccccc2C1=O)C(=O)O | Homo sapiens | CHEMBL1043577 | cell-based format |
| CHEMBL572060 |  |
IC50 | = | 1000.0 | nM | 288.32 | CSC1=C(/C=C(\C)C(=O)O)C(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL1043577 | cell-based format |
| CHEMBL577297 |  |
IC50 | = | 1000.0 | nM | 272.26 | COC1=C(/C=C(\C)C(=O)O)C(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL1043577 | cell-based format |