P27448 | MARK3_HUMAN | MAP/microtubule affinity-regulating kinase 3 (MARK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 56~307 | |
| PF00627 | UBA - UBA/TS-N domain | 328~363 | |
| PF02149 | KA1 - Kinase associated domain 1 | 710~753 |
3D structures mapped by conservation among orthologs
[ Domain: "RuvA-C, UBA, CRAL/TRIO-N, HBS1" // UBA_MELK ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4565845 |  |
IC50 | < | 0.25 | nM | 471.54 | Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(-c3cnn(C)c3)cnc12 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL388978 |  |
IC50 | = | 0.438 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328485 | single protein format |
| CHEMBL4568087 |  |
IC50 | <= | 0.5 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL3648448 |  |
IC50 | = | 0.5 | nM | 471.51 | N[C@@H]1CCCC(F)(F)C1NC(=O)c1cc(-c2cnc3cc(-c4ccc(F)cc4)cnn23)cs1 | Homo sapiens | CHEMBL3705161 | single protein format |
| CHEMBL4532781 |  |
IC50 | = | 1.0 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL4569508 |  |
IC50 | = | 1.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL3884319 |  |
IC50 | = | 1.2 | nM | 386.45 | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 | Homo sapiens | CHEMBL3876023 | single protein format |
| CHEMBL4550486 |  |
IC50 | = | 1.3 | nM | 435.56 | Cc1sc(C(=O)N[C@@H]2CCCC[C@@H]2N)cc1-c1cnn2cc(-c3cnn(C)c3)cnc12 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL4528550 |  |
IC50 | = | 2.0 | nM | 407.5 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL4552799 |  |
IC50 | = | 2.4 | nM | 391.45 | Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cccnc12 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL4562217 |  |
IC50 | = | 3.0 | nM | 407.5 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL5305160 |  |
IC50 | = | 3.0 | nM | 469.59 | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3cccc(CN4CCCC4)c3)ncc21 | Homo sapiens | CHEMBL5345919 | single protein format |
| CHEMBL4552628 |  |
IC50 | = | 5.0 | nM | 425.89 | Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL4593028 |  |
IC50 | = | 5.0 | nM | 476.48 | COCCOc1ccc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cc1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL4550702 |  |
IC50 | = | 6.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL4579339 |  |
IC50 | = | 9.0 | nM | 422.51 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5O)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL4571737 |  |
IC50 | = | 9.0 | nM | 408.49 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NC(CO)C5CC5)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479676 | assay format |
| CHEMBL3883979 |  |
IC50 | = | 10.0 | nM | 385.47 | CC1(C)C(=O)N([C@H]2CCc3c(N)cccc32)c2nc(Nc3ccccc3)ncc21 | Homo sapiens | CHEMBL3876023 | single protein format |
| CHEMBL3884318 |  |
IC50 | = | 10.0 | nM | 375.43 | C[C@@H](c1cccc(O)c1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 | Homo sapiens | CHEMBL3876023 | single protein format |
| CHEMBL4543195 |  |
IC50 | = | 10.0 | nM | 408.49 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@H]5O)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479676 | assay format |