P27361 | MK03_HUMAN | Mitogen-activated protein kinase 3 (MAPK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 42~330 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3544964 |  |
IC50 | = | 1.2 | nM | 440.87 | Cn1nccc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 | Homo sapiens | CHEMBL3620376 | single protein format |
| CHEMBL4434915 |  |
IC50 | = | 1.5 | nM | 464.95 | O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)ccc2CN1C(CO)c1cccc(Cl)c1 | Homo sapiens | CHEMBL4423399 | single protein format |
| CHEMBL4650280 |  |
IC50 | = | 2.0 | nM | 473.94 | Cc1cnc(NC2CCOCC2)nc1-n1cnc(C(=O)N[C@H](CN)c2cc(F)cc(Cl)c2)c1 | Homo sapiens | CHEMBL5152487 | single protein format |
| CHEMBL3409588 |  |
IC50 | = | 2.7 | nM | 444.89 | O=c1cc(-c2ccnc(NC3CCOCC3)n2)ccn1[C@H](CO)c1ccc(Cl)c(F)c1 | Homo sapiens | CHEMBL4425911 | single protein format |
| CHEMBL5070887 |  |
IC50 | = | 2.75 | nM | 463.93 | Cc1cnc(Nc2ccnn2C)nc1-c1cc2n(c1)C(=O)N([C@H](CO)c1cccc(Cl)c1)C2 | Homo sapiens | CHEMBL5050747 | single protein format |
| CHEMBL4588783 |  |
IC50 | = | 3.3 | nM | 434.93 | O=C1c2cc(-c3ccnc(NC4CCOCC4)n3)ccc2CN1Cc1cccc(Cl)c1 | Homo sapiens | CHEMBL4423399 | single protein format |
| CHEMBL4567212 |  |
IC50 | = | 3.6 | nM | 460.93 | Cn1nccc1Nc1nccc(-c2ccc3c(c2)C(=O)N(C(CO)c2cccc(Cl)c2)C3)n1 | Homo sapiens | CHEMBL4423399 | single protein format |
| CHEMBL4565958 |  |
IC50 | = | 3.8 | nM | 440.87 | Cc1n[nH]cc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 | Homo sapiens | CHEMBL4425911 | single protein format |
| CHEMBL4571067 |  |
IC50 | = | 3.9 | nM | 451.89 | Cc1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)ccn1 | Homo sapiens | CHEMBL4425911 | single protein format |
| CHEMBL3590107 |  |
IC50 | = | 4.0 | nM | 587.69 | O=C(Nc1ccc2[nH]nc(-c3ccncc3)c2c1)[C@@H]1CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1 | Homo sapiens | CHEMBL3620378 | single protein format |
| CHEMBL4532652 |  |
IC50 | = | 4.1 | nM | 460.93 | Cn1cc(Nc2nccc(-c3ccc4c(c3)C(=O)N(C(CO)c3cccc(Cl)c3)C4)n2)cn1 | Homo sapiens | CHEMBL4423399 | single protein format |
| CHEMBL4436718 |  |
IC50 | = | 5.0 | nM | 454.89 | CCn1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)cn1 | Homo sapiens | CHEMBL4425911 | single protein format |
| CHEMBL4650285 |  |
IC50 | = | 5.0 | nM | 453.57 | Cn1nccc1Nc1nccc(-c2cc3c(s2)C(C)(C)N(CCN2CCOCC2)C3=O)n1 | Homo sapiens | CHEMBL5152487 | single protein format |
| CHEMBL4435650 |  |
IC50 | = | 7.9 | nM | 440.87 | Cn1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)cn1 | Homo sapiens | CHEMBL4425911 | single protein format |
| CHEMBL5183609 |  |
IC50 | = | 10.0 | nM | 458.44 | C=CC(=O)Nc1cc(C)ccc1Nc1nc(Nc2cc(OC)ncc2C)ncc1C(F)(F)F | Homo sapiens | CHEMBL5152487 | single protein format |
| CHEMBL4650284 |  |
IC50 | = | 10.0 | nM | 355.4 | O=C1Nc2cc3[nH]nc(-c4ccncc4)c3cc2CN1Cc1ccccc1 | Homo sapiens | CHEMBL5152487 | single protein format |
| CHEMBL4114404 |  |
IC50 | = | 13.0 | nM | 454.89 | Cc1nn(C)cc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 | Homo sapiens | CHEMBL4425911 | single protein format |
| CHEMBL3797917 |  |
IC50 | = | 16.7 | nM | 446.73 | Cc1cc(-c2n[nH]c3ccc(C(=O)NCc4c(Cl)cnc(Cl)c4Cl)cc23)ccn1 | Homo sapiens | CHEMBL3802287 | assay format |
| CHEMBL3675721 |  |
IC50 | = | 18.0 | nM | 468.92 | CCn1cc(Nc2nccc(-c3ccn([C@H](CO)c4ccc(Cl)c(F)c4)c(=O)c3)n2)c(C)n1 | Homo sapiens | CHEMBL4425911 | single protein format |
| CHEMBL1336 |  |
IC50 | = | 18.1 | nM | 464.83 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | Homo sapiens | CHEMBL3580222 | single protein format |