P26639 | SYTC_HUMAN | Threonine--tRNA ligase 1, cytoplasmic (TARS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00587 | tRNA-synt_2b - tRNA synthetase class II core domain (G, H, P, S and T) | 399~608 | |
| PF02824 | TGS - TGS domain | 83~143 | |
| PF03129 | HGTP_anticodon - Anticodon binding domain | 620~710 | |
| PF07973 | tRNA_SAD - Threonyl and Alanyl tRNA synthetase second additional domain | 250~298 |
3D structures mapped by conservation among orthologs
[ Domain: "Ubiquitin-like" // TGS ]
[ Domain: "Class II aaRS and biotin synthetases" // tRNA-synt_2b ]
[ Domain: "Anticodon-binding domain of Class II aaRS" // HGTP_anticodon ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1163068 |  |
IC50 | = | 15.0 | nM | 447.43 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL816522 | single protein format |
| CHEMBL2311920 |  |
Ki | = | 1.2 | nM | 435.89 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(N)nc(Cl)nc3c2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311926 |  |
Ki | = | 1.8 | nM | 425.47 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1ccc2ccc(-c3ncnc4[nH]ccc34)cc2c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311924 |  |
Ki | = | 3.0 | nM | 401.45 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1ccc2ccc(-c3cc(N)ncn3)cc2c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311918 |  |
Ki | = | 3.3 | nM | 401.45 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(N)ncnc3c2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311925 |  |
Ki | = | 4.1 | nM | 377.43 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)/C=C/c1cccc(-c2cc(N)ncn2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311927 |  |
Ki | = | 5.2 | nM | 430.49 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)N1CCc2ccc(-c3ncnc4[nH]ccc34)cc2C1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311919 |  |
Ki | = | 10.1 | nM | 416.46 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(N)nc(N)nc3c2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311917 |  |
Ki | = | 13.4 | nM | 447.43 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)OC[C@@H]1O[C@H](n2cnc3c(N)ncnc32)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2316966 |  |
Ki | = | 32.0 | nM | 391.45 | CC[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)/C=C/c1cccc(-c2cc(N)ncn2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311921 |  |
Ki | = | 72.0 | nM | 415.48 | Cc1nc(N)c2ccc(-c3cccc(S(=O)(=O)NC(=O)[C@@H](N)[C@@H](C)O)c3)cc2n1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311928 |  |
Ki | = | 91.0 | nM | 389.43 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(c2)CNC3=O)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2316963 |  |
Ki | = | 399.0 | nM | 386.84 | C[C@@H](O)[C@H](N)C(=O)NNc1cccc(-c2ccc3c(N)nc(Cl)nc3c2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2311922 |  |
Ki | = | 463.0 | nM | 434.91 | C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(N)nc(Cl)cc3c2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2316967 |  |
Ki | = | 601.0 | nM | 405.48 | CC(C)[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)/C=C/c1cccc(-c2cc(N)ncn2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |
| CHEMBL2316962 |  |
Ki | = | 935.0 | nM | 385.86 | C[C@@H](O)[C@H](N)C(=O)NCc1cccc(-c2ccc3c(N)nc(Cl)nc3c2)c1 | Homo sapiens | CHEMBL2317882 | single protein format |