P26358 | DNMT1_HUMAN | DNA (cytosine-5)-methyltransferase 1 (DNMT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00145 | DNA_methylase - C-5 cytosine-specific DNA methylase | 1140~1593 | |
| PF01426 | BAH - BAH domain | 755~880 | |
| PF01426 | BAH - BAH domain | 932~1100 | |
| PF02008 | zf-CXXC - CXXC zinc finger domain | 646~691 | |
| PF06464 | DMAP_binding - DMAP1-binding Domain | 18~103 | |
| PF12047 | DNMT1-RFD - Cytosine specific DNA methyltransferase replication foci domain | 400~533 |
3D structures mapped by conservation among orthologs
[ Domain: "Replication foci-targeting sequence N-terminal domain" // DNMT1-RFD ]
[ Domain: "SH3" // BAH_1 ]
[ Domain: "SH3" // BAH_2 ]
[ Domain: "Replication foci-targeting sequence C-terminal domain" // DNMT1-RFD_C ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // DNA_methylase ]
[ Domain: "CXXC domain" // zf-CXXC ]
[ Domain: "CXXC domain" // UNK_F_TYPE ]
[ Domain: "C-terminal Zn-binding domain in DNA (cytosine-5)-methyltransferase 1" // EUF08665 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2171169 |  |
IC50 | = | 2.9 | nM | 540.67 | CC(C)N(CCCNC(=O)Nc1ccc(C(C)(C)C)cc1)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O | Homo sapiens | CHEMBL4479553 | single protein format |
| CHEMBL4215326 |  |
IC50 | = | 21.0 | nM | 476.62 | COc1cc2c(NC3CCN(C)CC3)cc(-c3ccc(C)o3)nc2cc1OC1CC2(C1)CN(C)C2 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL1201129 |  |
IC50 | = | 30.0 | nM | 228.21 | Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1 | Homo sapiens | CHEMBL4137467 | single protein format |
| CHEMBL4208004 |  |
IC50 | = | 32.0 | nM | 492.66 | COc1cc2c(NCC3CCN(C)CC3)cc(-c3ccc(C)o3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4212905 |  |
IC50 | = | 40.0 | nM | 506.69 | CCc1ccc(-c2cc(NCC3CCN(C)CC3)c3cc(OC)c(OCCCN4CCCC4)cc3n2)o1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4208010 |  |
IC50 | = | 73.0 | nM | 464.61 | COc1cc2c(NC3CCN(C)CC3)cc(-c3ccc(C)o3)nc2cc1OCC1CCNCC1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4211688 |  |
IC50 | = | 80.0 | nM | 532.73 | CCc1ccc(-c2cc(NCC3C4CCC3CN(C)C4)c3cc(OC)c(OCCCN4CCCC4)cc3n2)o1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4215862 |  |
IC50 | = | 83.0 | nM | 504.68 | COc1cc2c(NC3CCN(C)CC3)cc(-c3ccc(C)o3)nc2cc1OC1CC2(C1)CN(C(C)C)C2 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4203133 |  |
IC50 | = | 83.0 | nM | 478.64 | COc1cc2c(NC3CCN(C)CC3)cc(-c3ccc(C)o3)nc2cc1OCC1CCN(C)CC1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL1564869 |  |
IC50 | = | 115.0 | nM | 334.33 | O=C(O)[C@H](Cc1c[nH]c2ccccc12)N1C(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL4836935 | single protein format |
| CHEMBL3126646 |  |
IC50 | = | 120.0 | nM | 461.53 | Cc1cc(Nc2cccc(NC(=O)c3cccc(Nc4ccnc5ccccc45)c3)c2)nc(N)n1 | Homo sapiens | CHEMBL3129170 | single protein format |
| CHEMBL4208812 |  |
IC50 | = | 123.0 | nM | 518.7 | COc1cc2c(NC3CCC34CCN(C)CC4)cc(-c3ccc(C)o3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4163329 |  |
IC50 | = | 137.0 | nM | 464.61 | COc1cc2c(NC3CCNCC3)cc(-c3ccc(C)o3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4137467 | single protein format |
| CHEMBL4206035 |  |
IC50 | = | 140.0 | nM | 518.7 | COc1cc2c(NC3CC4(CCN(C)CC4)C3)cc(-c3ccc(C)o3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4588797 |  |
IC50 | = | 150.0 | nM | 408.44 | N#Cc1cn([C@@H]2O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]2O)c2ncnc(N)c12 | Homo sapiens | CHEMBL4479553 | single protein format |
| CHEMBL4216593 |  |
IC50 | = | 187.0 | nM | 544.74 | COc1cc2c(NC3CC4(CCN(C(C)C)CC4)C3)cc(-c3ccc(C)o3)nc2cc1OC1CC2(C1)CN(C)C2 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4213346 |  |
IC50 | = | 200.0 | nM | 518.7 | COc1cc2c(NC3CC4(CCN(C)CC4)C3)cc(-c3ccc(C)o3)nc2cc1OCC1CCN(C)CC1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4216144 |  |
IC50 | = | 201.0 | nM | 504.68 | COc1cc2c(NC3CC4(CCN(C)C4)C3)cc(-c3ccc(C)o3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4203647 |  |
IC50 | = | 205.0 | nM | 520.72 | COc1cc2c(NCC3CCN(C(C)C)CC3)cc(-c3ccc(C)o3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4195563 | single protein format |
| CHEMBL4204482 |  |
IC50 | = | 211.0 | nM | 546.76 | COc1cc2c(NC3CC4(CCN(C(C)C)CC4)C3)cc(-c3ccc(C)o3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4195563 | single protein format |