P25929 | NPY1R_HUMAN | Neuropeptide Y receptor type 1 (NPY1R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 57~320 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1 ]
[ Domain: "Lysozyme-like" // Phage_lysozyme_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4128926 |  |
IC50 | = | 0.13 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121491 | single protein format |
| CHEMBL567112 |  |
IC50 | = | 0.13 | nM | 473.64 | CCc1sc(SCc2cc(N3CCOCC3)cc(NCc3cccc(C)n3)n2)nc1CF | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL585669 |  |
IC50 | = | 0.16 | nM | 441.63 | Cc1cccc(CNc2cc(N3CCSCC3)cc(CSc3nc(C)c(C)o3)n2)n1 | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL585711 |  |
IC50 | = | 0.2 | nM | 459.62 | Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(CF)c(C)s3)n2)n1 | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL566020 |  |
IC50 | = | 0.27 | nM | 445.59 | Cc1nc(SCc2cc(N3CCSCC3)cc(NCc3cccc(F)n3)n2)oc1C | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL566041 |  |
IC50 | = | 0.27 | nM | 441.63 | Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(C)s3)n2)n1 | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL567101 |  |
IC50 | = | 0.39 | nM | 439.59 | CCc1oc(SCc2cc(N3CCOCC3)cc(NCc3cccc(C)n3)n2)nc1C | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL566040 |  |
IC50 | = | 0.46 | nM | 451.6 | Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc4c(o3)CCCC4)n2)n1 | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL566255 |  |
IC50 | = | 0.56 | nM | 459.62 | Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(CF)s3)n2)n1 | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL567719 |  |
IC50 | = | 0.69 | nM | 425.56 | Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(C)o3)n2)n1 | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL1774204 |  |
IC50 | = | 0.69 | nM | 529.65 | N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 | Homo sapiens | CHEMBL5463882 | cell-based format |
| CHEMBL116680 |  |
IC50 | < | 1.0 | nM | 564.73 | COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCCN2CCC(C(C)(C)C)CC2)NC#N)c1 | Homo sapiens | CHEMBL756251 | cell-based format |
| CHEMBL50184 |  |
IC50 | = | 1.4 | nM | 558.15 | CCc1sc(CCc2cc(N3CCOCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C | Homo sapiens | CHEMBL756252 | cell-based format |
| CHEMBL567928 |  |
IC50 | = | 1.5 | nM | 429.52 | Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(F)n3)n2)oc1C | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL566889 |  |
IC50 | = | 1.7 | nM | 473.62 | Cc1cccc(CNc2cc(N3CCS(=O)(=O)CC3)cc(CSc3nc(C)c(C)o3)n2)n1 | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL567941 |  |
IC50 | = | 1.8 | nM | 443.55 | Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(CF)n3)n2)oc1C | Homo sapiens | CHEMBL1042012 | cell-based format |
| CHEMBL188271 |  |
IC50 | = | 2.0 | nM | 561.68 | COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3)CC2)c1 | Homo sapiens | CHEMBL827935 | cell-based format |
| CHEMBL187555 |  |
IC50 | = | 2.0 | nM | 591.71 | COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3OC)CC2)c1 | Homo sapiens | CHEMBL827935 | cell-based format |
| CHEMBL187399 |  |
IC50 | = | 3.0 | nM | 586.69 | COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3C#N)CC2)c1 | Homo sapiens | CHEMBL827935 | cell-based format |
| CHEMBL361273 |  |
IC50 | = | 4.0 | nM | 599.74 | COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3C)CC2)NC#N)c1 | Homo sapiens | CHEMBL827935 | cell-based format |