P25106 | ACKR3_HUMAN | Atypical chemokine receptor 3 (ACKR3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 62~315 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4758472 |  |
IC50 | = | 0.37 | nM | 551.64 | CC(C)(NC(=O)[C@H]1CN(C2CCCCC2)CC[C@@H]1NC(=O)c1cc(-c2ccc(F)cc2F)on1)c1ccccn1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4799528 |  |
IC50 | = | 0.6 | nM | 536.58 | O=C(N[C@H]1CCN(CC2CCC2)C[C@@H]1C(=O)NC1(c2ncccn2)CC1)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4794973 |  |
IC50 | = | 0.75 | nM | 550.61 | O=C(N[C@H]1CCN(C2CCCCC2)C[C@@H]1C(=O)NC1(c2ncccn2)CC1)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4753893 |  |
IC50 | = | 1.5 | nM | 460.53 | CN(C)C(=O)[C@@H]1CN(C2CCCCC2)CC[C@H]1NC(=O)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4741307 |  |
IC50 | = | 1.9 | nM | 536.58 | O=C(N[C@H]1CCN(C2CCCC2)C[C@@H]1C(=O)NC1(c2ncccn2)CC1)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4744654 |  |
IC50 | = | 2.0 | nM | 419.47 | CO[C@H]1CN(C2CCCCC2)CC[C@@H]1NC(=O)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4795114 |  |
IC50 | = | 2.0 | nM | 447.48 | COC(=O)[C@H]1CN(C2CCCCC2)CC[C@@H]1NC(=O)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4794569 |  |
IC50 | = | 2.0 | nM | 405.45 | O=C(N[C@H]1CCN(C2CCCCC2)C[C@@H]1O)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4740027 |  |
IC50 | = | 2.7 | nM | 536.62 | O=C(N[C@H]1CCN(C2CCCCC2)C[C@@H]1C(=O)NCCc1ccccc1)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4758009 |  |
IC50 | = | 2.7 | nM | 536.58 | CC1(CN2CC[C@H](NC(=O)c3cc(-c4ccc(F)cc4F)on3)[C@@H](C(=O)NC3(c4ncccn4)CC3)C2)CC1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4782111 |  |
IC50 | = | 3.2 | nM | 522.56 | O=C(N[C@H]1CCN(CC2CC2)C[C@@H]1C(=O)NC1(c2ncccn2)CC1)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4789874 |  |
IC50 | = | 4.2 | nM | 549.62 | O=C(N[C@H]1CCN(C2CCCCC2)C[C@@H]1C(=O)NC1(c2ccccn2)CC1)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4794487 |  |
IC50 | = | 5.0 | nM | 389.45 | O=C(NC1CCN(C2CCCCC2)CC1)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4752112 |  |
IC50 | = | 5.0 | nM | 419.47 | O=C(N[C@H]1CCN(C2CCCCC2)C[C@@H]1CO)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4759284 |  |
IC50 | = | 5.0 | nM | 433.5 | CCO[C@H]1CN(C2CCCCC2)CC[C@@H]1NC(=O)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4764929 |  |
IC50 | = | 5.5 | nM | 536.62 | C[C@@H](NC(=O)[C@H]1CN(C2CCCCC2)CC[C@@H]1NC(=O)c1cc(-c2ccc(F)cc2F)on1)c1ccccc1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4755755 |  |
IC50 | = | 6.7 | nM | 537.61 | C[C@@H](NC(=O)[C@H]1CN(C2CCCCC2)CC[C@@H]1NC(=O)c1cc(-c2ccc(F)cc2F)on1)c1ccccn1 | Homo sapiens | CHEMBL4706356 | cell-based format |
| CHEMBL4746586 |  |
IC50 | = | 7.0 | nM | 390.43 | O=C(NC1CCN(C2CCCCC2)CC1)c1nnc(-c2ccc(F)cc2F)o1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4747997 |  |
IC50 | = | 7.4 | nM | 460.53 | CN(C)C(=O)[C@H]1CN(C2CCCCC2)CC[C@@H]1NC(=O)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706355 | cell-based format |
| CHEMBL4761704 |  |
IC50 | = | 8.7 | nM | 537.61 | O=C(N[C@H]1CCN(C2CCCCC2)C[C@@H]1C(=O)NCCc1ccccn1)c1cc(-c2ccc(F)cc2F)on1 | Homo sapiens | CHEMBL4706356 | cell-based format |