P25105 | PTAFR_HUMAN | Platelet-activating factor receptor (PTAFR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 33~293 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL157078 |  |
IC50 | = | 0.015 | nM | 430.57 | CCOC[C@H](CC(C)C)NS(=O)(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 | Homo sapiens | CHEMBL764537 | assay format |
| CHEMBL277701 |  |
IC50 | = | 0.2 | nM | 498.01 | Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL1235246 |  |
IC50 | = | 0.28 | nM | 523.69 | CCCCCCCCCCCCCCCCOC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC(C)=O | Homo sapiens | CHEMBL2395085 | assay format |
| CHEMBL20195 |  |
IC50 | = | 0.3 | nM | 499.0 | Cc1nnc2n1-c1sc(C#CCn3c(=O)n(C)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL19640 |  |
IC50 | = | 0.6 | nM | 527.01 | Cc1nnc2n1-c1sc(C#CCn3c(=O)n(C)c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL20019 |  |
IC50 | = | 0.7 | nM | 524.05 | Cc1nnc2n1-c1sc(C#CCC34CCCc5cccc(c53)NC4=O)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL19747 |  |
IC50 | = | 0.7 | nM | 499.98 | Cc1nnc2n1-c1sc(C#CCN3C(=O)COc4ccccc43)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL283162 |  |
IC50 | = | 1.0 | nM | 468.97 | Cc1nnc2n1-c1sc(C#CCn3ncc4ccccc43)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL281779 |  |
IC50 | = | 1.0 | nM | 561.07 | Cc1nnc2n1-c1sc(C#CCn3c(=O)n(-c4ccccc4)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL99294 |  |
IC50 | = | 1.0 | nM | 430.59 | CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccccc12 | Homo sapiens | CHEMBL765344 | assay format |
| CHEMBL282883 |  |
IC50 | = | 1.0 | nM | 496.0 | Cc1nnc2n1-c1sc(C#CCn3ccc4ccccc4c3=O)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL296149 |  |
IC50 | = | 2.0 | nM | 442.56 | COc1cccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2cccc(OC)c2)c1 | Homo sapiens | CHEMBL767099 | assay format |
| CHEMBL279665 |  |
IC50 | = | 2.0 | nM | 496.0 | Cc1nnc2n1-c1sc(C#CCn3c(=O)ccc4ccccc43)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL57676 |  |
IC50 | = | 2.0 | nM | 426.56 | COc1ccc(/C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccccc2)cc1 | Homo sapiens | CHEMBL767099 | assay format |
| CHEMBL156461 |  |
IC50 | = | 2.3 | nM | 396.56 | O=C([C@@H]1CSC(c2cccnc2)N1)N1CCN(CCCc2ccccc2)CC1 | Homo sapiens | CHEMBL764537 | assay format |
| CHEMBL20163 |  |
IC50 | = | 3.0 | nM | 444.95 | Cc1nnc2n1-c1sc(C#CCOc3ccccc3)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL34548 |  |
IC50 | = | 3.0 | nM | 401.89 | COc1ccc(C2CCC(OCCCn3c(C)nc4cnccc43)O2)cc1Cl | Homo sapiens | CHEMBL764097 | assay format |
| CHEMBL99924 |  |
IC50 | = | 3.0 | nM | 460.62 | CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccc(OC)cc12 | Homo sapiens | CHEMBL765344 | assay format |
| CHEMBL429066 |  |
IC50 | = | 3.0 | nM | 483.98 | Cc1nnc2n1-c1sc(C#CCN3C(=O)Cc4ccccc43)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |
| CHEMBL283339 |  |
IC50 | = | 4.0 | nM | 445.94 | Cc1nnc2n1-c1sc(C#CCOc3cccnc3)cc1C(c1ccccc1Cl)=NC2 | Homo sapiens | CHEMBL667333 | assay format |