P25101 | EDNRA_HUMAN | Endothelin-1 receptor (EDNRA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 97~367 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL289634 |  |
IC50 | = | 0.011 | nM | 532.64 | COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL411925 |  |
IC50 | = | 0.011 | nM | 532.64 | CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL432856 |  |
IC50 | = | 0.014 | nM | 518.61 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL294291 |  |
IC50 | = | 0.02 | nM | 481.98 | CC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | Homo sapiens | CHEMBL679122 | single protein format |
| CHEMBL60058 |  |
IC50 | = | 0.02 | nM | 482.97 | C/C(=N\O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | Homo sapiens | CHEMBL679122 | single protein format |
| CHEMBL35984 |  |
IC50 | = | 0.022 | nM | 504.58 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL4128926 |  |
IC50 | = | 0.023 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121477 | single protein format |
| CHEMBL287683 |  |
IC50 | = | 0.024 | nM | 559.66 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL37427 |  |
IC50 | = | 0.027 | nM | 531.61 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL304460 |  |
IC50 | = | 0.03 | nM | 504.01 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(C)(=O)=O)c1 | Homo sapiens | CHEMBL679122 | single protein format |
| CHEMBL60367 |  |
IC50 | = | 0.03 | nM | 496.01 | CCC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | Homo sapiens | CHEMBL679122 | single protein format |
| CHEMBL293830 |  |
IC50 | = | 0.03 | nM | 493.99 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CC2)c1 | Homo sapiens | CHEMBL679122 | single protein format |
| CHEMBL287622 |  |
IC50 | = | 0.031 | nM | 490.56 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL60149 |  |
IC50 | = | 0.04 | nM | 469.93 | COC(=O)c1cc(C)ccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | Homo sapiens | CHEMBL679122 | single protein format |
| CHEMBL416324 |  |
IC50 | = | 0.04 | nM | 497.0 | CO/N=C(\C)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | Homo sapiens | CHEMBL679122 | single protein format |
| CHEMBL19950 |  |
IC50 | = | 0.04 | nM | 467.96 | CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl | Homo sapiens | CHEMBL679122 | single protein format |
| CHEMBL323464 |  |
IC50 | = | 0.044 | nM | 564.68 | CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 | Homo sapiens | CHEMBL873596 | cell-based format |
| CHEMBL36627 |  |
IC50 | = | 0.047 | nM | 476.53 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL286621 |  |
IC50 | = | 0.048 | nM | 520.58 | COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 | Homo sapiens | CHEMBL682364 | single protein format |
| CHEMBL291592 |  |
IC50 | = | 0.05 | nM | 532.07 | Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(=O)(=O)C(C)C)c1 | Homo sapiens | CHEMBL679122 | single protein format |