P25100 | ADA1D_HUMAN | Alpha-1D adrenergic receptor (ADRA1D)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 113~402 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2 |  |
IC50 | = | 0.656 | nM | 383.41 | COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL723 |  |
IC50 | = | 1.796 | nM | 406.48 | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL1909072 |  |
IC50 | = | 1.944 | nM | 401.96 | NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL3582270 |  |
IC50 | = | 2.2 | nM | 599.65 | CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 | Homo sapiens | CHEMBL3583057 | cell-based format |
| CHEMBL707 |  |
IC50 | = | 3.383 | nM | 451.48 | COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL71 |  |
IC50 | = | 3.991 | nM | 318.87 | CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL3582268 |  |
IC50 | < | 5.0 | nM | 477.48 | COc1cc2nc(N3CCN(C(=O)c4cc5ccc(O)cc5oc4=O)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL3583057 | cell-based format |
| CHEMBL3582269 |  |
IC50 | < | 5.0 | nM | 544.53 | COc1cc2nc(N3CCN(C(=O)c4cn(-c5cc6ccc(O)cc6oc5=O)nn4)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL3583057 | cell-based format |
| CHEMBL479 |  |
IC50 | = | 5.891 | nM | 370.59 | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL1201216 |  |
IC50 | = | 8.312 | nM | 325.46 | Cc1ccccc1N1CCN(CCc2nnc3n2CCCC3)CC1 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL85 |  |
IC50 | = | 9.995 | nM | 410.49 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL3742276 |  |
IC50 | = | 10.07 | nM | 503.62 | CS(=O)(=O)c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744075 | single protein format |
| CHEMBL3739533 |  |
IC50 | = | 11.31 | nM | 426.52 | O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccn3)CC2)cc1 | Homo sapiens | CHEMBL3744075 | single protein format |
| CHEMBL3742253 |  |
IC50 | = | 12.87 | nM | 493.53 | O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 | Homo sapiens | CHEMBL3744075 | single protein format |
| CHEMBL564 |  |
IC50 | = | 13.0 | nM | 284.43 | CN(C)CCCN1c2ccccc2Sc2ccccc21 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL3739762 |  |
IC50 | = | 16.73 | nM | 450.54 | [C-]#[N+]c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744075 | single protein format |
| CHEMBL611 |  |
IC50 | = | 17.0 | nM | 387.44 | COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL1385840 |  |
IC50 | = | 18.0 | nM | 561.68 | CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL597 |  |
IC50 | = | 22.0 | nM | 281.36 | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 | Homo sapiens | CHEMBL1909087 | cell membrane format |
| CHEMBL1732 |  |
IC50 | = | 29.0 | nM | 583.69 | CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 | Homo sapiens | CHEMBL1909087 | cell membrane format |