P25024 | CXCR1_HUMAN | C-X-C chemokine receptor type 1 (CXCR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 56~305 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4442431 |  |
IC50 | = | 0.1 | nM | 397.33 | C[C@@H](C(=O)[N-]S(C)(=O)=O)c1ccc(OS(=O)(=O)C(F)(F)F)cc1.[Na+] | Homo sapiens | CHEMBL4309942 | single protein format |
| CHEMBL191413 |  |
IC50 | = | 1.0 | nM | 283.39 | CC(C)Cc1ccc([C@@H](C)C(=O)NS(C)(=O)=O)cc1 | Homo sapiens | CHEMBL2184854 | single protein format |
| CHEMBL246108 |  |
IC50 | = | 7.3 | nM | 425.49 | CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(C(C)C)co1 | Homo sapiens | CHEMBL886376 | cell-based format |
| CHEMBL376414 |  |
IC50 | = | 11.0 | nM | 425.49 | Cc1ccc([C@H](Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C(C)(C)C)o1 | Homo sapiens | CHEMBL912816 | cell-based format |
| CHEMBL139 |  |
IC50 | = | 12.0 | nM | 296.15 | O=C(O)Cc1ccccc1Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL1055471 | cell-based format |
| CHEMBL3913959 |  |
IC50 | = | 20.0 | nM | 526.04 | Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N(C)C)c3O)c(=O)c2=O)C2CCCS2)o1 | Homo sapiens | CHEMBL3888716 | assay format |
| CHEMBL184637 |  |
IC50 | = | 22.0 | nM | 323.15 | O=C(Nc1ccc(O)cc1O)Nc1ccccc1Br | Homo sapiens | CHEMBL828738 | single protein format |
| CHEMBL239767 |  |
IC50 | = | 22.0 | nM | 352.14 | O=C(Nc1ccc([N+](=O)[O-])cc1O)Nc1ccccc1Br | Homo sapiens | CHEMBL2184855 | cell-based format |
| CHEMBL218115 |  |
IC50 | = | 26.0 | nM | 383.4 | CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccco1 | Homo sapiens | CHEMBL912816 | cell-based format |
| CHEMBL3952996 |  |
IC50 | = | 30.0 | nM | 581.12 | Cc1ccc(C(Nc2c(Nc3ccc(Cl)c(S(=O)(=O)N4CCN(C)CC4)c3O)c(=O)c2=O)C2CCCS2)o1 | Homo sapiens | CHEMBL3888716 | assay format |
| CHEMBL3426944 |  |
IC50 | = | 31.0 | nM | 466.22 | O=C(Nc1ccc(F)cc1)c1ccc(SCc2cc(OC(F)(F)F)ccc2B(O)O)nc1 | Homo sapiens | CHEMBL3427961 | cell-based format |
| CHEMBL384889 |  |
IC50 | = | 34.0 | nM | 411.46 | Cc1ccc([C@H](Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C(C)C)o1 | Homo sapiens | CHEMBL912816 | cell-based format |
| CHEMBL238510 |  |
IC50 | = | 36.0 | nM | 325.28 | O=c1c(Nc2ccccc2)c(Nc2ccc([N+](=O)[O-])cc2O)c1=O | Homo sapiens | CHEMBL5215021 | single protein format |
| CHEMBL216981 |  |
IC50 | = | 36.0 | nM | 397.43 | CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1 | Homo sapiens | CHEMBL912816 | cell-based format |
| CHEMBL3904195 |  |
IC50 | = | 42.0 | nM | 513.57 | COC(=O)CN(C)C(=O)c1cccc(Nc2c(N[C@@H](c3ccc(C)o3)C3CCCS3)c(=O)c2=O)c1O | Homo sapiens | CHEMBL3888716 | assay format |
| CHEMBL401939 |  |
IC50 | = | 55.0 | nM | 462.3 | CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(Br)co1 | Homo sapiens | CHEMBL927215 | single protein format |
| CHEMBL216603 |  |
IC50 | = | 55.0 | nM | 409.44 | Cc1ccc([C@H](Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2CC2)o1 | Homo sapiens | CHEMBL912816 | cell-based format |
| CHEMBL218387 |  |
IC50 | = | 55.0 | nM | 472.75 | CN(C)S(=O)(=O)c1c(Cl)ccc(N/C(=N/C#N)Nc2ccccc2Br)c1O | Homo sapiens | CHEMBL908414 | cell-based format |
| CHEMBL253714 |  |
IC50 | = | 62.0 | nM | 417.85 | CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cc(Cl)co1 | Homo sapiens | CHEMBL927215 | single protein format |
| CHEMBL252851 |  |
IC50 | = | 67.0 | nM | 383.4 | CCC(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccco1 | Homo sapiens | CHEMBL927215 | single protein format |