P25021 | HRH2_HUMAN | Histamine H2 receptor (HRH2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 35~288 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL194837 |  |
IC50 | = | 0.87 | nM | 448.35 | Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 | Homo sapiens | CHEMBL881891 | single protein format |
| CHEMBL269646 |  |
IC50 | = | 22.0 | nM | 312.43 | C/N=C(/NC#N)NCCSCc1csc(NC(=N)N)n1 | Homo sapiens | CHEMBL2395102 | cell-based format |
| CHEMBL902 |  |
IC50 | = | 42.0 | nM | 337.46 | NC(N)=Nc1nc(CSCC/C(N)=N/S(N)(=O)=O)cs1 | Homo sapiens | CHEMBL1909157 | cell membrane format |
| CHEMBL222927 |  |
IC50 | < | 100.0 | nM | 442.58 | CCOCCn1cc(C2CCN(CCOc3ccsc3C(=O)O)CC2)c2ccccc21 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL404849 |  |
IC50 | = | 108.1 | nM | 337.57 | CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 | Homo sapiens | CHEMBL1909157 | cell membrane format |
| CHEMBL223024 |  |
IC50 | = | 123.0 | nM | 436.55 | CCOCCn1cc(C2CCN(CCOc3cccc(C(=O)O)c3)CC2)c2ccccc21 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL4128926 |  |
IC50 | = | 142.0 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121483 | single protein format |
| CHEMBL30 |  |
IC50 | = | 180.0 | nM | 252.35 | CN/C(=N\CCSCc1nc[nH]c1C)NC#N | Homo sapiens | CHEMBL947354 | single protein format |
| CHEMBL516 |  |
IC50 | = | 198.0 | nM | 287.41 | CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 | Homo sapiens | CHEMBL1909157 | cell membrane format |
| CHEMBL221462 |  |
IC50 | = | 225.0 | nM | 450.58 | CCOCCn1cc(C2CCN(CCOc3ccc(C)cc3C(=O)O)CC2)c2ccccc21 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL221413 |  |
IC50 | = | 260.0 | nM | 454.54 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2ccc(F)cc21 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL116463 |  |
IC50 | = | 368.0 | nM | 517.62 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | Homo sapiens | CHEMBL697133 | single protein format |
| CHEMBL1626 |  |
IC50 | = | 370.0 | nM | 343.9 | CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL1909157 | cell membrane format |
| CHEMBL21731 |  |
IC50 | = | 400.0 | nM | 277.41 | CNCCCC12CCC(c3ccccc31)c1ccccc12 | Homo sapiens | CHEMBL1909157 | cell membrane format |
| CHEMBL221414 |  |
IC50 | = | 500.0 | nM | 594.34 | CCOCCn1cc(C2CCN(CCOc3c(Br)cc(Br)cc3C(=O)O)CC2)c2ccccc21 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL374585 |  |
IC50 | = | 500.0 | nM | 454.54 | CCOCCn1cc(C2CCN(CCOc3ccccc3C(=O)O)CC2)c2cc(F)ccc21 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL222881 |  |
IC50 | = | 500.0 | nM | 460.6 | O=C(O)c1ccccc1OCCN1CCC(c2cn(Cc3cccs3)c3ccccc23)CC1 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL222985 |  |
IC50 | = | 630.0 | nM | 414.51 | O=C(O)c1cccc(CN2CCC(c3cn(Cc4ccco4)c4ccccc34)CC2)c1 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL222853 |  |
IC50 | = | 691.0 | nM | 436.55 | CCOCCn1cc(C2CCN(CCOc3ccc(C(=O)O)cc3)CC2)c2ccccc21 | Homo sapiens | CHEMBL914453 | cell membrane format |
| CHEMBL629 |  |
IC50 | = | 730.0 | nM | 277.41 | CN(C)CCC=C1c2ccccc2CCc2ccccc21 | Homo sapiens | CHEMBL1909157 | cell membrane format |