P24723 | KPCL_HUMAN | Protein kinase C eta type (PRKCH)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 356~614 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 172~225 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 246~297 | |
| PF00168 | C2 - C2 domain | 10~115 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 635~676 |
3D structures mapped by conservation among orthologs
[ Domain: "C2 domain" // RNAse_Pc_like,C2_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL48636 |  |
IC50 | = | 0.6 | nM | 521.48 | O=C(NC1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL772753 | single protein format |
| CHEMBL427118 |  |
IC50 | = | 0.6 | nM | 521.48 | O=C(N[C@@H]1CCCC1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL758469 | single protein format |
| CHEMBL52529 |  |
IC50 | = | 0.6 | nM | 521.48 | O=C(N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL767397 | single protein format |
| CHEMBL1996510 |  |
IC50 | = | 1.0 | nM | 424.46 | O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 | Homo sapiens | CHEMBL2156015 | single protein format |
| CHEMBL71331 |  |
IC50 | = | 1.0 | nM | 521.48 | O=C(NC1CCC[C@@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL767402 | single protein format |
| CHEMBL2151411 |  |
IC50 | = | 1.7 | nM | 452.52 | Cc1cccc2c(C3=C(c4nc(N5CCN(C)CC5)nc5ccccc45)C(=O)NC3=O)c[nH]c12 | Homo sapiens | CHEMBL2156015 | single protein format |
| CHEMBL2153750 |  |
IC50 | = | 1.9 | nM | 456.48 | CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(F)ccc3n2)CC1 | Homo sapiens | CHEMBL2156015 | single protein format |
| CHEMBL306427 |  |
IC50 | = | 2.0 | nM | 551.5 | O=C(N[C@H]1C[C@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL770098 | single protein format |
| CHEMBL75661 |  |
IC50 | = | 2.0 | nM | 551.5 | O=C(N[C@@H]1C[C@H](CO)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL770096 | single protein format |
| CHEMBL494089 |  |
IC50 | = | 2.0 | nM | 425.49 | CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 | Homo sapiens | CHEMBL1028105 | single protein format |
| CHEMBL2147537 |  |
IC50 | = | 2.0 | nM | 279.35 | C[C@H](N)CNc1nc(-c2ccncc2)cc2cnccc12 | Homo sapiens | CHEMBL2150524 | single protein format |
| CHEMBL417051 |  |
IC50 | = | 2.0 | nM | 536.49 | N[C@@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL770098 | single protein format |
| CHEMBL432168 |  |
IC50 | = | 3.0 | nM | 536.49 | N[C@@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL770096 | single protein format |
| CHEMBL295806 |  |
IC50 | = | 3.0 | nM | 492.48 | O=C(OC1CCCC1Cc1ccc(O)cc1)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1 | Homo sapiens | CHEMBL772753 | single protein format |
| CHEMBL59677 |  |
IC50 | = | 3.0 | nM | 521.48 | O=C(N[C@@H]1CNC[C@H]1NC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL767401 | single protein format |
| CHEMBL306580 |  |
IC50 | = | 3.0 | nM | 537.48 | O=C(N[C@@H]1CC(O)C[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 | Homo sapiens | CHEMBL770096 | single protein format |
| CHEMBL308263 |  |
IC50 | = | 3.0 | nM | 550.52 | NC[C@@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL770096 | single protein format |
| CHEMBL421866 |  |
IC50 | = | 3.0 | nM | 550.52 | NC[C@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL770098 | single protein format |
| CHEMBL307708 |  |
IC50 | = | 3.0 | nM | 550.52 | NC[C@H]1C[C@@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL770096 | single protein format |
| CHEMBL67290 |  |
IC50 | = | 3.0 | nM | 550.52 | NC[C@@H]1C[C@H](NC(=O)c2ccc(O)cc2)[C@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(=O)O)c(O)c2)C1 | Homo sapiens | CHEMBL770098 | single protein format |