P24666 | PPAC_HUMAN | Low molecular weight phosphotyrosine protein phosphatase (ACP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01451 | LMWPc - Low molecular weight phosphotyrosine protein phosphatase | 9~154 |
3D structures mapped by conservation among orthologs
[ Domain: "Phosphotyrosine protein phosphatases I-like" // LMWPc ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5218807 |  |
IC50 | = | 4.0 | nM | 388.04 | Cc1c(Br)cc(NC(=O)NS(=O)(=O)O)cc1Br | Homo sapiens | CHEMBL5217153 | assay format |
| CHEMBL4875137 |  |
IC50 | = | 6.0 | nM | 385.26 | Cc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cncc3Cl)c-2n1 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL5219822 |  |
IC50 | = | 8.0 | nM | 397.25 | N.O=C(Nc1ccc(N2CCOCC2)c(Br)c1)NS(=O)(=O)O | Homo sapiens | CHEMBL5217153 | assay format |
| CHEMBL4856707 |  |
IC50 | = | 20.0 | nM | 384.27 | Cc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c-2n1 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL5218783 |  |
IC50 | = | 49.0 | nM | 240.27 | N.O=C(Nc1nccs1)NS(=O)(=O)O | Homo sapiens | CHEMBL5217153 | assay format |
| CHEMBL5220687 |  |
IC50 | = | 56.0 | nM | 290.33 | N.O=C(Nc1nc2ccccc2s1)NS(=O)(=O)O | Homo sapiens | CHEMBL5217153 | assay format |
| CHEMBL4857535 |  |
IC50 | = | 83.0 | nM | 295.13 | Nc1ncn(Cc2c(Cl)cncc2Cl)c2ncnc1-2 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL4855952 |  |
IC50 | = | 87.0 | nM | 384.27 | Cc1cccc(-c2nc3c(N)ncn(Cc4c(Cl)cccc4Cl)c-3n2)c1 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL4874911 |  |
IC50 | = | 104.0 | nM | 370.24 | Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(-c3ccccc3)nc1-2 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL4848127 |  |
IC50 | = | 106.0 | nM | 400.27 | COc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c-2n1 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL4873827 |  |
IC50 | = | 117.0 | nM | 388.23 | Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(-c3ccc(F)cc3)nc1-2 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL4859307 |  |
IC50 | = | 119.0 | nM | 384.27 | Cc1ccc(-c2nc3c(N)ncn(Cc4c(Cl)cccc4Cl)c-3n2)cc1 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL5220615 |  |
IC50 | = | 121.0 | nM | 233.25 | N.O=C(Nc1ccccc1)NS(=O)(=O)O | Homo sapiens | CHEMBL5217153 | assay format |
| CHEMBL4858034 |  |
IC50 | = | 147.0 | nM | 388.23 | Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(-c3ccccc3F)nc1-2 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL4861843 |  |
IC50 | = | 171.0 | nM | 404.69 | Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(-c3ccccc3Cl)nc1-2 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL5220051 |  |
IC50 | = | 200.0 | nM | 317.3 | O=C(CS(=O)(=O)O)Nc1nc2ccc([N+](=O)[O-])cc2s1 | Homo sapiens | CHEMBL5217153 | assay format |
| CHEMBL1765349 |  |
IC50 | = | 220.0 | nM | 564.62 | O=C(O)c1ccc(COc2cccc(/C=C3\S/C(=N\c4ccccc4)N(Cc4ccc(C(=O)O)cc4)C3=O)c2)cc1 | Homo sapiens | CHEMBL2163148 | single protein format |
| CHEMBL4870698 |  |
IC50 | = | 239.0 | nM | 388.23 | Nc1ncn(Cc2c(Cl)cccc2Cl)c2nc(-c3cccc(F)c3)nc1-2 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL4847980 |  |
IC50 | = | 239.0 | nM | 294.14 | Nc1ncn(Cc2c(Cl)cccc2Cl)c2ncnc1-2 | Homo sapiens | CHEMBL4837935 | single protein format |
| CHEMBL4868378 |  |
IC50 | = | 245.0 | nM | 395.25 | N#Cc1ccccc1-c1nc2c(N)ncn(Cc3c(Cl)cccc3Cl)c-2n1 | Homo sapiens | CHEMBL4837935 | single protein format |