P24557 | THAS_HUMAN | Thromboxane-A synthase (TBXAS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 46~297 | |
| PF00067 | p450 - Cytochrome P450 | 325~525 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL136762 |  |
IC50 | = | 1.0 | nM | 436.55 | O=C(O)CCC(CCCCNS(=O)(=O)c1ccc(F)cc1)CCCc1cccnc1 | Homo sapiens | CHEMBL813715 | single protein format |
| CHEMBL435590 |  |
IC50 | = | 1.0 | nM | 432.59 | Cc1ccc(S(=O)(=O)NCCCCC(CCCc2cccnc2)CCC(=O)O)cc1 | Homo sapiens | CHEMBL813715 | single protein format |
| CHEMBL338420 |  |
IC50 | = | 1.0 | nM | 480.56 | O=C(O)CCC/C=C(/c1cccnc1)c1ccc2c(c1)CC(NS(=O)(=O)c1ccc(F)cc1)C2 | Homo sapiens | CHEMBL816624 | assay format |
| CHEMBL137402 |  |
IC50 | = | 1.0 | nM | 467.03 | Cc1ccncc1CCCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCC(=O)O | Homo sapiens | CHEMBL813715 | single protein format |
| CHEMBL136738 |  |
IC50 | = | 1.5 | nM | 468.62 | O=C(O)CCC(CCCCNS(=O)(=O)c1ccc2ccccc2c1)CCCc1cccnc1 | Homo sapiens | CHEMBL813715 | single protein format |
| CHEMBL139372 |  |
IC50 | = | 2.0 | nM | 486.56 | O=C(O)CCC(CCCCNS(=O)(=O)c1ccc(C(F)(F)F)cc1)CCCc1cccnc1 | Homo sapiens | CHEMBL813715 | single protein format |
| CHEMBL65414 |  |
IC50 | = | 2.0 | nM | 453.0 | O=C(O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 | Homo sapiens | CHEMBL808526 | single protein format |
| CHEMBL339269 |  |
IC50 | = | 2.0 | nM | 487.02 | O=C(O)CCCCC(c1ccc(CCNS(=O)(=O)c2ccc(Cl)cc2)cc1)c1cccnc1 | Homo sapiens | CHEMBL816624 | assay format |
| CHEMBL341686 |  |
IC50 | = | 2.0 | nM | 471.04 | O=C(O)CSC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1cccnc1 | Homo sapiens | CHEMBL813715 | single protein format |
| CHEMBL301550 |  |
IC50 | = | 2.0 | nM | 356.85 | Cn1c(-c2cccnc2)c(CCCCCC(=O)O)c2cc(Cl)ccc21 | Homo sapiens | CHEMBL816621 | assay format |
| CHEMBL53346 |  |
IC50 | = | 2.3 | nM | 399.49 | O=C([O-])CCC/C=C\C[C@H]1[C@@H]2CCC(C2)[C@@H]1NS(=O)(=O)c1ccccc1.[Na+] | Homo sapiens | CHEMBL812847 | assay format |
| CHEMBL151083 |  |
IC50 | = | 2.6 | nM | 511.58 | O=C(O)CCCC/C=C(\c1ccc(-c2nc(C(=O)NCCOc3ccccc3)co2)cc1)c1cccnc1 | Homo sapiens | CHEMBL814386 | single protein format |
| CHEMBL151091 |  |
IC50 | = | 2.7 | nM | 539.63 | COc1ccc(CCCNC(=O)c2coc(-c3ccc(/C(=C\CCCCC(=O)O)c4cccnc4)cc3)n2)cc1 | Homo sapiens | CHEMBL814386 | single protein format |
| CHEMBL26820 |  |
IC50 | = | 2.9 | nM | 281.36 | O=C(O)CCCC/C=C(\c1ccccc1)c1cccnc1 | Homo sapiens | CHEMBL811638 | assay format |
| CHEMBL21954 |  |
IC50 | = | 3.0 | nM | 520.66 | CC(C)(C)/N=C(\Nc1cccc(/C(=C\CCCC(=O)O)c2cccnc2)c1)NS(=O)(=O)c1ccccc1 | Homo sapiens | CHEMBL813721 | assay format |
| CHEMBL136371 |  |
IC50 | = | 3.0 | nM | 469.0 | O=C(O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCc1ccc[n+]([O-])c1 | Homo sapiens | CHEMBL813715 | single protein format |
| CHEMBL134580 |  |
IC50 | = | 3.0 | nM | 441.98 | O=C(O)CCC(CCCCNS(=O)(=O)c1ccc(Cl)cc1)CCCn1ccnc1 | Homo sapiens | CHEMBL813715 | single protein format |
| CHEMBL21852 |  |
IC50 | = | 3.0 | nM | 483.62 | N#CN/C(=N/C12CC3CC(CC(C3)C1)C2)Nc1cccc(/C(=C\CCCC(=O)O)c2cccnc2)c1 | Homo sapiens | CHEMBL813721 | assay format |
| CHEMBL416374 |  |
IC50 | = | 3.0 | nM | 419.53 | CC(C)CC/N=C(/NC#N)Nc1cccc(/C(=C\CCCC(=O)O)c2cccnc2)c1 | Homo sapiens | CHEMBL813721 | assay format |
| CHEMBL48092 |  |
IC50 | = | 3.0 | nM | 232.28 | O=C(O)CCCCCc1cccc2cncn12 | Homo sapiens | CHEMBL808526 | single protein format |