P23946 | CMA1_HUMAN | Chymase (CMA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00089 | Trypsin - Trypsin | 22~240 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3640120 |  |
IC50 | = | 0.3 | nM | 462.55 | CCCCC(CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cc(C)cc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640116 |  |
IC50 | = | 0.4 | nM | 434.5 | CC[C@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cc(C)cc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL1631751 |  |
IC50 | = | 0.46 | nM | 498.63 | C[C@@H](NC(=O)N1C(=O)[C@@H](Cc2ccccc2)[C@H]1Oc1ccc(N2CCN(C)CC2)cc1)c1ccccc1 | Homo sapiens | CHEMBL1639355 | single protein format |
| CHEMBL3640118 |  |
IC50 | = | 0.7 | nM | 434.5 | CC[C@H](CC(=O)O)n1c(=O)c2cnccc2n(Cc2cn(C)c3cc(C)cc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640115 |  |
IC50 | = | 0.7 | nM | 446.51 | Cc1cc(C)c2c(Cn3c(=O)n(C(CC(=O)O)C4CC4)c(=O)c4ncccc43)cn(C)c2c1 | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL44950 |  |
IC50 | = | 0.85 | nM | 354.32 | O=C1N(Cc2ccc3c(c2)OCO3)C(=O)N1Cc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL883537 | single protein format |
| CHEMBL3640105 |  |
IC50 | = | 0.9 | nM | 434.5 | CCCC[C@H](C(=O)O)n1c(=O)c2cnccc2n(Cc2cn(C)c3cccc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640121 |  |
IC50 | = | 1.3 | nM | 434.5 | CCCC(CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cccc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640119 |  |
IC50 | = | 1.4 | nM | 448.52 | CCCCC(CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cccc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640110 |  |
IC50 | = | 1.4 | nM | 420.47 | CC[C@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cccc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL48083 |  |
IC50 | = | 2.0 | nM | 326.35 | COc1ccc(CN2C(=O)N(Cc3ccc(OC)cc3)C2=O)cc1 | Homo sapiens | CHEMBL883537 | single protein format |
| CHEMBL3640102 |  |
IC50 | = | 2.1 | nM | 420.47 | CCC[C@@H](C(=O)O)n1c(=O)c2cnccc2n(Cc2cn(C)c3cccc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640111 |  |
IC50 | = | 2.2 | nM | 438.51 | CC[C@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2nsc3cc(C)cc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL45780 |  |
IC50 | = | 2.3 | nM | 326.35 | COc1cccc(CN2C(=O)N(Cc3cccc(OC)c3)C2=O)c1 | Homo sapiens | CHEMBL883537 | single protein format |
| CHEMBL3639389 |  |
IC50 | = | 2.5 | nM | 420.47 | CC[C@H](CC(=O)O)n1c(=O)c2cnccc2n(Cc2cn(C)c3cccc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640114 |  |
IC50 | = | 2.6 | nM | 424.48 | CC[C@H](C(=O)O)n1c(=O)c2cnccc2n(Cc2nsc3cc(C)cc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640100 |  |
IC50 | = | 2.6 | nM | 452.54 | CCCC[C@H](C(=O)O)n1c(=O)c2cnccc2n(Cc2nsc3cc(C)cc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640117 |  |
IC50 | = | 2.7 | nM | 424.48 | CC[C@@H](C(=O)O)n1c(=O)c2ncccc2n(Cc2nsc3cc(C)cc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL3640107 |  |
IC50 | = | 3.0 | nM | 420.47 | CC[C@@H](CC(=O)O)n1c(=O)c2ncccc2n(Cc2cn(C)c3cccc(C)c23)c1=O | Homo sapiens | CHEMBL3705301 | single protein format |
| CHEMBL1631756 |  |
IC50 | = | 3.1 | nM | 550.61 | CCOc1ccccc1C[C@@H]1C(=O)N(C(=O)NC(c2ccccc2)c2ccccc2)[C@@H]1Oc1ccc(C(=O)O)cc1 | Homo sapiens | CHEMBL1639355 | single protein format |