P23743 | DGKA_HUMAN | Diacylglycerol kinase alpha (DGKA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 206~254 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 270~321 | |
| PF00609 | DAGK_acc - Diacylglycerol kinase accessory domain | 521~701 | |
| PF00781 | DAGK_cat - Diacylglycerol kinase catalytic domain | 376~485 | |
| PF14513 | DAG_kinase_N - Diacylglycerol kinase N-terminus | 6~89 |
3D structures mapped by conservation among orthologs
[ Domain: "EF-hand" // DAG_kinase_N ]
[ Domain: "EF-hand" // EF-hand_7_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5424446 |  |
IC50 | = | 5.0 | nM | 516.51 | Cn1c(=O)c([N+](=O)[O-])c(N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c2nc(C#N)ccc21 | Homo sapiens | CHEMBL5363628 | single protein format |
| CHEMBL5408449 |  |
IC50 | = | 15.0 | nM | 454.53 | Cn1c(=O)c([N+](=O)[O-])c(N2CCN(C(c3ccccc3)c3ccccc3)CC2)c2ccccc21 | Homo sapiens | CHEMBL5363628 | single protein format |
| CHEMBL5402920 |  |
IC50 | = | 34.0 | nM | 515.52 | Cn1c(=O)c([N+](=O)[O-])c(N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c2cc(C#N)ccc21 | Homo sapiens | CHEMBL5363628 | single protein format |
| CHEMBL5413938 |  |
IC50 | = | 53.0 | nM | 491.5 | Cn1c(=O)c([N+](=O)[O-])c(N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c2ncccc21 | Homo sapiens | CHEMBL5363628 | single protein format |
| CHEMBL4645744 |  |
IC50 | = | 190.0 | nM | 499.57 | C[C@@H]1CN(c2cc(=O)n(C)c3ccc(C#N)nc23)[C@@H](C)CN1C(c1ccc(F)cc1)c1ccc(F)cc1 | Homo sapiens | CHEMBL4618780 | cell-based format |
| CHEMBL261131 |  |
IC50 | = | 300.0 | nM | 489.59 | O=c1c2ccccc2[nH]c(=S)n1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL4413403 | cell-based format |
| CHEMBL4648848 |  |
IC50 | = | 580.0 | nM | 499.57 | C[C@@H]1CN(c2cc(=O)n(C)c3ccc(C#N)nc23)[C@@H](C)CN1C(c1ccc(F)cc1)c1ccccc1F | Homo sapiens | CHEMBL4618780 | cell-based format |
| CHEMBL1416439 |  |
IC50 | = | 600.0 | nM | 392.48 | O=C1/C(=C/C=C/c2ccco2)SC(=S)N1NS(=O)(=O)c1ccccc1 | Homo sapiens | CHEMBL5363628 | single protein format |
| CHEMBL4647083 |  |
IC50 | = | 770.0 | nM | 543.46 | C[C@@H]1CN(c2c(C#N)c(=O)n(C)c3ccc(C#N)nc23)CCN1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4618780 | cell-based format |