P23526 | SAHH_HUMAN | Adenosylhomocysteinase (AHCY)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00670 | AdoHcyase_NAD - S-adenosyl-L-homocysteine hydrolase, NAD binding domain | 191~352 | |
| PF05221 | AdoHcyase - S-adenosyl-L-homocysteine hydrolase | 7~141 |
3D structures mapped by conservation among orthologs
[ Domain: "NAD(P)-binding Rossmann-fold domains" // AdoHcyase_NAD ]
[ Domain: "Formate/glycerate dehydrogenase catalytic domain-like" // AdoHcyase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3322562 |  |
IC50 | = | 5.0 | nM | 592.96 | CNCCNC(=O)CN(CC(=O)N(C)N1Cc2ccccc2C1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1.Cl | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL2115462 |  |
IC50 | = | 8.0 | nM | 283.26 | Nc1ncnc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@@H](CO)[C@H]1F | Homo sapiens | CHEMBL800621 | assay format |
| CHEMBL3322547 |  |
IC50 | = | 13.0 | nM | 596.56 | CN(C(=O)CN(CC(=O)NCCN1CCCC1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1)N1Cc2ccccc2C1 | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL3290658 |  |
IC50 | = | 16.0 | nM | 268.7 | Nc1ncc(Cl)c2c1ncn2[C@@H]1CC[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL3294635 | single protein format |
| CHEMBL281337 |  |
IC50 | = | 18.0 | nM | 264.29 | Nc1ccnc2c1ncn2[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL800629 | single protein format |
| CHEMBL3290663 |  |
IC50 | = | 24.0 | nM | 268.25 | Nc1ncc(F)c2c1ncn2[C@@H]1C[C@H](O)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL3294635 | single protein format |
| CHEMBL3290665 |  |
IC50 | = | 28.0 | nM | 250.23 | Nc1ncc(F)c2c1ncn2[C@@H]1C=C[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL3294636 | cell-based format |
| CHEMBL284846 |  |
IC50 | = | 31.0 | nM | 262.27 | Nc1nccc2c1ncn2C1C=C(CO)C(O)C1O | Homo sapiens | CHEMBL800629 | single protein format |
| CHEMBL3290657 |  |
IC50 | = | 40.0 | nM | 252.25 | Nc1ncc(F)c2c1ncn2[C@@H]1CC[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL3294635 | single protein format |
| CHEMBL3322556 |  |
IC50 | = | 49.0 | nM | 583.56 | CC(C)NCCNC(=O)CN(CC(=O)N(C)C1Cc2ccccc2C1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1 | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL3322540 |  |
IC50 | = | 52.0 | nM | 595.57 | CN(C(=O)CN(CC(=O)NCCN1CCCC1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1)C1Cc2ccccc2C1 | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL301499 |  |
IC50 | = | 55.0 | nM | 235.25 | Nc1ncnc2c1ncn2[C@@H]1CC[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL3294635 | single protein format |
| CHEMBL3322555 |  |
IC50 | = | 60.0 | nM | 569.53 | CCNCCNC(=O)CN(CC(=O)N(C)C1Cc2ccccc2C1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1 | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL3322554 |  |
IC50 | = | 70.0 | nM | 555.51 | CNCCNC(=O)CN(CC(=O)N(C)C1Cc2ccccc2C1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1 | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL53931 |  |
IC50 | = | 80.0 | nM | 277.28 | C=C1C(CO)C(O)C(O)C1n1cnc2c(N)ncnc21 | Homo sapiens | CHEMBL800621 | assay format |
| CHEMBL3290655 |  |
IC50 | = | 98.0 | nM | 253.24 | Nc1nc(F)nc2c1ncn2[C@@H]1CC[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL3294636 | cell-based format |
| CHEMBL3322559 |  |
IC50 | = | 110.0 | nM | 581.54 | CN(C(=O)CN(CC(=O)NC[C@@H]1CCCN1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1)C1Cc2ccccc2C1 | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL3322553 |  |
IC50 | = | 130.0 | nM | 569.53 | CN(C)CCNC(=O)CN(CC(=O)N(C)C1Cc2ccccc2C1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1 | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL3322561 |  |
IC50 | = | 150.0 | nM | 595.57 | CN(C(=O)CN(CC(=O)NCC1CCCCN1)c1cc(Cl)ccc1Oc1ccc(Cl)cc1)C1Cc2ccccc2C1 | Homo sapiens | CHEMBL3367518 | single protein format |
| CHEMBL2115031 |  |
IC50 | = | 180.0 | nM | 283.26 | Nc1ncnc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@@H](CO)[C@@H]1F | Homo sapiens | CHEMBL800621 | assay format |