P23467 | PTPRB_HUMAN | Receptor-type tyrosine-protein phosphatase beta (PTPRB)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00041fn3118–195
PF00041fn3207–275
PF00041fn3292–364
PF00041fn3379–454
PF00041fn3470–543
PF00041fn3556–635
PF00041fn3644–727
PF00041fn3733–809
PF00041fn3821–894
PF00041fn3908–982
PF00041fn3998–1078
PF00041fn31087–1161
PF00041fn31176–1253
PF00041fn31262–1348
PF00041fn31357–1438
PF00102Y_phosphatase1727–1960
PF18861PTP_tm1473–1609

 3D structures mapped by conservation among orthologs

[ Domain: "(Phosphotyrosine protein) phosphatases II" // Y_phosphatase ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3976968 IC50 < 5e-05 nM 552.7 COC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1nc(-c2cccs2)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3919353 IC50 < 5e-05 nM 586.74 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1nc(C2CCCCC2)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3931971 IC50 < 5e-05 nM 586.72 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1csc(-c2cccs2)n1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3911932 IC50 < 5e-05 nM 586.72 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1nc(-c2cccs2)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3932657 IC50 < 0.0007 nM 580.69 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1csc(-c2ccccc2)n1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3915642 IC50 < 0.002 nM 580.69 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1nc(-c2ccccc2)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3914134 IC50 = 0.009 nM 576.78 Cc1nc(Cc2nnc(N[C@@H](Cc3ccc(NS(=O)(=O)O)cc3)c3csc(-c4cccs4)n3)s2)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3928885 IC50 = 0.01 nM 544.66 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1nc(C2CC2)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3963181 IC50 = 0.09 nM 586.72 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1nc(-c2ccsc2)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3967271 IC50 = 0.1 nM 532.64 CCc1nc([C@H](Cc2ccc(NS(=O)(=O)O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3962687 IC50 = 0.1 nM 546.67 CCc1nc([C@H](Cc2ccc(NS(=O)(=O)O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC)sc1C Homo sapiens CHEMBL3880089 single protein format
CHEMBL3907615 IC50 = 0.1 nM 546.67 CCCc1csc([C@H](Cc2ccc(NS(=O)(=O)O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC)n1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3945835 IC50 = 0.14 nM 546.67 CCOC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1nc(CC)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3921571 IC50 = 0.157 nM 445.57 CCc1csc([C@H](Cc2ccc(NS(=O)(=O)O)cc2)NC(=O)Cc2ccccc2)n1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3891215 IC50 = 0.162 nM 532.64 CCc1csc([C@H](Cc2ccc(NS(=O)(=O)O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC)n1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3946325 IC50 = 0.2 nM 544.66 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1csc(C2CC2)n1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3956877 IC50 = 0.2 nM 560.7 COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(=O)(=O)O)cc1)c1nc(C(C)(C)C)cs1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3900884 IC50 = 0.2 nM 576.65 CCOC(=O)c1csc([C@H](Cc2ccc(NS(=O)(=O)O)cc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)OC)n1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3924295 IC50 = 0.2 nM 507.69 CCCc1nnc(N[C@@H](Cc2ccc(NS(=O)(=O)O)cc2)c2csc(-c3cccs3)n2)s1 Homo sapiens CHEMBL3880089 single protein format
CHEMBL3966138 IC50 = 0.2 nM 494.04 CCc1csc([C@H](Cc2ccc(NS(=O)(=O)O)cc2)NC(=O)CCc2cccc(Cl)c2)n1 Homo sapiens CHEMBL3880089 single protein format