P23458 | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 585~844 | |
PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 876~1147 | |
PF17887 | Jak1_Phl - Jak1 pleckstrin homology-like domain | 284~421 | |
PF18377 | FERM_F2 - FERM F2 acyl-CoA binding protein-like domain | 147~277 | |
PF18379 | FERM_F1 - FERM F1 ubiquitin-like domain | 38~128 | |
PF21990 | SH2_1 - SH2 domain | 438~546 |
3D structures mapped by conservation among orthologs
[ Domain: "PH domain-like" // FERM_C_TYK2 ]
[ Domain: "Acyl-CoA binding protein-like" // B41_C ]
[ Domain: "SH2" // SH2_1 ]
[ Domain: "Ubiquitin-like" // B41_N ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL3652408 | IC50 | = | 0.00125 | nM | 465.62 | COCCOC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3652407 | IC50 | = | 0.00133 | nM | 463.65 | CC(C)COC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3652404 | IC50 | = | 0.00199 | nM | 421.57 | C[C@H]1CN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C[C@@H]1CO | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3652402 | IC50 | = | 0.00508 | nM | 421.57 | C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3652406 | IC50 | = | 0.00777 | nM | 407.54 | CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)C2)CC1 | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3896068 | IC50 | = | 0.01 | nM | 517.47 | N#CCC1(n2cc(C(N)=O)c(Nc3ccc(-c4cn[nH]c4)nc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 | Homo sapiens | CHEMBL3888428 | single protein format | |
CHEMBL3947540 | IC50 | = | 0.02 | nM | 534.51 | N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(NCC(F)(F)F)CC1 | Homo sapiens | CHEMBL3888428 | single protein format | |
CHEMBL4078799 | IC50 | = | 0.02 | nM | 391.44 | Cn1cc(-c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc2)cn1 | Homo sapiens | CHEMBL4033003 | assay format | |
CHEMBL3652403 | IC50 | = | 0.0227 | nM | 491.66 | CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OC(=O)C(C)(C)C)C2)CC1 | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3652409 | IC50 | = | 0.0235 | nM | 543.63 | CCOP(=O)(OCC)O[C@@H]1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3652405 | IC50 | = | 0.0245 | nM | 406.56 | CN1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)CC1 | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3652410 | IC50 | = | 0.0263 | nM | 487.52 | CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OP(=O)(O)O)C2)CC1 | Homo sapiens | CHEMBL3707925 | single protein format | |
CHEMBL3897977 | IC50 | = | 0.03 | nM | 481.96 | N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccccc2Cl)CC1 | Homo sapiens | CHEMBL3888428 | single protein format | |
CHEMBL3904265 | IC50 | = | 0.03 | nM | 469.47 | N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(F)cc2F)CC1 | Homo sapiens | CHEMBL3888428 | single protein format | |
CHEMBL3965448 | IC50 | = | 0.03 | nM | 469.4 | N#CC[C@@]1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC(F)F)C[C@@H]1F | Homo sapiens | CHEMBL3888428 | single protein format | |
CHEMBL4113249 | IC50 | = | 0.03 | nM | 405.41 | C[C@](O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1)C(F)F | Homo sapiens | CHEMBL3888748 | single protein format | |
CHEMBL3929513 | IC50 | = | 0.03 | nM | 531.5 | Cn1cc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OCC(F)(F)F)CC4)cc3C(N)=O)cn2)cn1 | Homo sapiens | CHEMBL3888428 | single protein format | |
CHEMBL3703048 | IC50 | = | 0.04 | nM | 476.5 | C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F | Homo sapiens | CHEMBL3706329 | single protein format | |
CHEMBL3950253 | IC50 | = | 0.04 | nM | 451.48 | N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccc2F)CC1 | Homo sapiens | CHEMBL3888428 | single protein format | |
CHEMBL4066906 | IC50 | = | 0.04 | nM | 416.46 | C[C@@H]1NS(=O)(=O)c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc21 | Homo sapiens | CHEMBL4033003 | assay format |