P23458 | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (JAK1)

Pfam Domain Table

AccessionDomainRangeColor
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase585~844
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase876~1147
PF17887Jak1_Phl - Jak1 pleckstrin homology-like domain284~421
PF18377FERM_F2 - FERM F2 acyl-CoA binding protein-like domain147~277
PF18379FERM_F1 - FERM F1 ubiquitin-like domain38~128
PF21990SH2_1 - SH2 domain438~546

3D structures mapped by conservation among orthologs

[ Domain: "PH domain-like" // FERM_C_TYK2 ]

 PyMOL session

[ Domain: "Acyl-CoA binding protein-like" // B41_C ]

 PyMOL session

[ Domain: "SH2" // SH2_1 ]

 PyMOL session

[ Domain: "Ubiquitin-like" // B41_N ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3652408 IC50 = 0.00125 nM 465.62 COCCOC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 Homo sapiens CHEMBL3707925 single protein format
CHEMBL3652407 IC50 = 0.00133 nM 463.65 CC(C)COC1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 Homo sapiens CHEMBL3707925 single protein format
CHEMBL3652404 IC50 = 0.00199 nM 421.57 C[C@H]1CN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C[C@@H]1CO Homo sapiens CHEMBL3707925 single protein format
CHEMBL3652402 IC50 = 0.00508 nM 421.57 C[C@@H]1C[C@@H](CS(=O)(=O)N2CC[C@H](CO)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12 Homo sapiens CHEMBL3707925 single protein format
CHEMBL3652406 IC50 = 0.00777 nM 407.54 CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC(C)(O)C2)CC1 Homo sapiens CHEMBL3707925 single protein format
CHEMBL3896068 IC50 = 0.01 nM 517.47 N#CCC1(n2cc(C(N)=O)c(Nc3ccc(-c4cn[nH]c4)nc3)n2)CCN(C(=O)OCC(F)(F)F)CC1 Homo sapiens CHEMBL3888428 single protein format
CHEMBL3947540 IC50 = 0.02 nM 534.51 N#CCC1(n2cc(C(N)=O)c(Nc3ccc(S(=O)(=O)C(F)F)cc3)n2)CCC(NCC(F)(F)F)CC1 Homo sapiens CHEMBL3888428 single protein format
CHEMBL4078799 IC50 = 0.02 nM 391.44 Cn1cc(-c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc2)cn1 Homo sapiens CHEMBL4033003 assay format
CHEMBL3652403 IC50 = 0.0227 nM 491.66 CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OC(=O)C(C)(C)C)C2)CC1 Homo sapiens CHEMBL3707925 single protein format
CHEMBL3652409 IC50 = 0.0235 nM 543.63 CCOP(=O)(OCC)O[C@@H]1CCCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)C1 Homo sapiens CHEMBL3707925 single protein format
CHEMBL3652405 IC50 = 0.0245 nM 406.56 CN1CCN(S(=O)(=O)C[C@H]2CC[C@H](N(C)c3ncnc4[nH]ccc34)CC2)CC1 Homo sapiens CHEMBL3707925 single protein format
CHEMBL3652410 IC50 = 0.0263 nM 487.52 CN(c1ncnc2[nH]ccc12)[C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@@H](OP(=O)(O)O)C2)CC1 Homo sapiens CHEMBL3707925 single protein format
CHEMBL3897977 IC50 = 0.03 nM 481.96 N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(NCc2ccccc2Cl)CC1 Homo sapiens CHEMBL3888428 single protein format
CHEMBL3904265 IC50 = 0.03 nM 469.47 N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccc(F)cc2F)CC1 Homo sapiens CHEMBL3888428 single protein format
CHEMBL3965448 IC50 = 0.03 nM 469.4 N#CC[C@@]1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCN(C(=O)OCC(F)F)C[C@@H]1F Homo sapiens CHEMBL3888428 single protein format
CHEMBL4113249 IC50 = 0.03 nM 405.41 C[C@](O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)cc2C(N)=O)cc1)C(F)F Homo sapiens CHEMBL3888748 single protein format
CHEMBL3929513 IC50 = 0.03 nM 531.5 Cn1cc(-c2ccc(Nc3nn(C4(CC#N)CCN(C(=O)OCC(F)(F)F)CC4)cc3C(N)=O)cn2)cn1 Homo sapiens CHEMBL3888428 single protein format
CHEMBL3703048 IC50 = 0.04 nM 476.5 C[C@@](O)(c1ccc(Nc2nn([C@H]3CC[C@@H](N4CCC4)C[C@@H]3C#N)cc2C(N)=O)cc1)C(F)(F)F Homo sapiens CHEMBL3706329 single protein format
CHEMBL3950253 IC50 = 0.04 nM 451.48 N#CCC1(n2cc(C(N)=O)c(Nc3ccnc(F)c3)n2)CCC(Nc2ccccc2F)CC1 Homo sapiens CHEMBL3888428 single protein format
CHEMBL4066906 IC50 = 0.04 nM 416.46 C[C@@H]1NS(=O)(=O)c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)cc3C(N)=O)cc21 Homo sapiens CHEMBL4033003 assay format