P23443 | KS6B1_HUMAN | Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 91~352 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 373~413 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3936990 |  |
IC50 | = | 0.06 | nM | 463.61 | CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CN(C)C2)CC1 | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3899716 |  |
IC50 | = | 0.1 | nM | 514.45 | Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4Br)CC3)n2)ccc1F | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3966806 |  |
IC50 | = | 0.11 | nM | 525.5 | CC(C)c1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4Br)CC3)n2)ccn1 | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3675393 |  |
IC50 | = | 0.12 | nM | 351.41 | CNCC(Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1ccccc1 | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3675394 |  |
IC50 | = | 0.14 | nM | 403.41 | CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3685328 |  |
IC50 | = | 0.2 | nM | 385.86 | CNC[C@@H](Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1cccc(Cl)c1 | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3906990 |  |
IC50 | = | 0.2 | nM | 498.05 | CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3980521 |  |
IC50 | = | 0.2 | nM | 530.57 | CC(C)CNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3981085 |  |
IC50 | = | 0.26 | nM | 451.55 | COc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CNC2)CC1 | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3675395 |  |
IC50 | = | 0.28 | nM | 280.38 | CNC[C@H](/N=C1\NC=NC2C=CCC=C12)c1ccccc1 | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3675396 |  |
IC50 | = | 0.36 | nM | 390.27 | CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3675397 |  |
IC50 | = | 0.39 | nM | 337.38 | COc1cc(C(N)=O)c2ncnc(N[C@H](CN)c3ccccc3)c2c1 | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3894849 |  |
IC50 | = | 0.4 | nM | 488.49 | CNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3675399 |  |
IC50 | = | 0.42 | nM | 369.4 | CNCC(Nc1ncnc2c(C(N)=O)cc(OC)cc12)c1cccc(F)c1 | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3675398 |  |
IC50 | = | 0.42 | nM | 476.49 | CNCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)c(F)c2)c1 | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3943127 |  |
IC50 | = | 0.44 | nM | 535.59 | CCNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2OC(C)C)CC1 | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3971598 |  |
IC50 | = | 0.5 | nM | 448.55 | Cc1cc(-c2cn(CCN(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3978595 |  |
IC50 | = | 0.5 | nM | 470.0 | Nc1ncnc(N2CCC(c3nc(-c4cccc(F)c4)cn3CCN3CCCC3)CC2)c1Cl | Homo sapiens | CHEMBL3887296 | single protein format |
| CHEMBL3675331 |  |
IC50 | = | 0.5 | nM | 367.41 | COc1ccc(C(CN)Nc2ncnc3c(C(N)=O)cccc23)cc1OC | Homo sapiens | CHEMBL3705357 | single protein format |
| CHEMBL3675326 |  |
IC50 | = | 0.5 | nM | 325.35 | NCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(F)c1 | Homo sapiens | CHEMBL3705357 | single protein format |