P23368 | MAOM_HUMAN | NAD-dependent malic enzyme, mitochondrial (ME2)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00390malic89–270
PF03949Malic_M280–534

 3D structures mapped by conservation among orthologs

[ Domain: "C-terminal domain of Malic enzyme" // Malic_M ]

 PyMOL session

[ Domain: "NAD(P)-binding Rossmann-fold domains" // Malic_M ]

 PyMOL session

[ Domain: "Aminoacid dehydrogenase-like, N-terminal domain" // malic ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5279096 IC50 = 150.0 nM 330.82 O=C(Cc1ccc(Cl)cc1)N1CCN(c2ccc(O)cc2)CC1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5284469 IC50 = 190.0 nM 296.37 O=C(Cc1ccccc1)N1CCN(c2ccc(O)cc2)CC1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL372408 IC50 = 200.0 nM 351.41 O=C1CC(N2CCN(c3ccc(O)cc3)CC2)C(=O)N1c1ccccc1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5267207 IC50 = 200.0 nM 295.3 O=C(Nc1nnn[nH]1)C1c2ccccc2OC2C=CC=CC21 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5287773 IC50 = 210.0 nM 314.36 O=C(Cc1ccc(F)cc1)N1CCN(c2ccc(O)cc2)CC1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5278951 IC50 = 220.0 nM 297.36 O=C(Nc1ccccc1)N1CCN(c2ccc(O)cc2)CC1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5275653 IC50 = 230.0 nM 308.38 O=C(/C=C/c1ccccc1)N1CCN(c2ccc(O)cc2)CC1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5289840 IC50 = 270.0 nM 310.4 O=C(CCc1ccccc1)N1CCN(c2ccc(O)cc2)CC1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5277536 IC50 = 270.0 nM 338.45 CC(C)(CC(=O)N1CCN(c2ccc(O)cc2)CC1)c1ccccc1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5284610 IC50 = 350.0 nM 382.5 CCCCOc1ccc(CCC(=O)N2CCN(c3ccc(O)cc3)CC2)cc1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5289950 IC50 = 360.0 nM 311.39 O=C(CN1CCN(c2ccc(O)cc2)CC1)Nc1ccccc1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5279230 IC50 = 390.0 nM 312.37 O=C(COc1ccccc1)N1CCN(c2ccc(O)cc2)CC1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5283020 IC50 = 410.0 nM 364.37 O=C(Cc1ccc(C(F)(F)F)cc1)N1CCN(c2ccc(O)cc2)CC1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5218866 IC50 = 420.0 nM 352.34 COc1ccc(C2=C(O)C(=O)C(c3ccc(OC)cc3)=C(O)C2=O)cc1 Homo sapiens CHEMBL5225648 single protein format
CHEMBL5278596 IC50 = 980.0 nM 297.36 O=C(Cc1ccccc1)N1CCN(c2ccc(O)cn2)CC1 Homo sapiens CHEMBL5225648 single protein format