P23219 | PGH1_HUMAN | Prostaglandin G/H synthase 1 (PTGS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03098 | An_peroxidase - Animal haem peroxidase | 222~571 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5206077 |  |
IC50 | = | 1.0 | nM | 378.34 | COc1ccc(-n2nc(OCC(F)(F)F)nc2-c2ccc(O[11CH3])cc2)cc1 | Homo sapiens | CHEMBL5152267 | single protein format |
| CHEMBL143776 |  |
IC50 | = | 1.0 | nM | 321.37 | Fc1ccc(-c2[nH]c(-c3ccc(F)cc3)c3c2C2CCC3C2)cc1 | Homo sapiens | CHEMBL767823 | single protein format |
| CHEMBL29583 |  |
IC50 | < | 1.0 | nM | 397.38 | COc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(S(N)(=O)=O)cc2)cc1 | Homo sapiens | CHEMBL772766 | single protein format |
| CHEMBL1945285 |  |
IC50 | = | 1.23 | nM | 224.27 | CC(C)Cc1ccc([C@H](CF)C(=O)O)cc1 | Homo sapiens | CHEMBL1948028 | cell-based format |
| CHEMBL259972 |  |
IC50 | = | 1.4 | nM | 339.35 | COc1ccc(-c2noc(CC(=O)O)c2-c2ccc(OC)cc2)cc1 | Homo sapiens | CHEMBL936640 | single protein format |
| CHEMBL75435 |  |
IC50 | = | 1.9 | nM | 254.29 | C[C@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c1 | Homo sapiens | CHEMBL768736 | single protein format |
| CHEMBL1232083 |  |
IC50 | = | 2.0 | nM | 385.17 | CC(C)COc1c(Cl)cc2c(c1Cl)O[C@@H](C(F)(F)F)C(C(=O)O)=C2 | Homo sapiens | CHEMBL1639902 | single protein format |
| CHEMBL1034 |  |
IC50 | = | 3.0 | nM | 318.14 | O=C([O-])Cc1ccccc1Nc1c(Cl)cccc1Cl.[Na+] | Homo sapiens | CHEMBL3053160 | single protein format |
| CHEMBL5184826 |  |
IC50 | = | 4.0 | nM | 330.35 | [2H]C([2H])([18F])Oc1nc(-c2ccc(OC)cc2)n(-c2ccc(OC)cc2)n1 | Homo sapiens | CHEMBL5152267 | single protein format |
| CHEMBL3427203 |  |
IC50 | = | 4.9 | nM | 311.34 | COc1ccc(-c2nc(OC)nn2-c2ccc(OC)cc2)cc1 | Homo sapiens | CHEMBL3428751 | single protein format |
| CHEMBL432945 |  |
IC50 | = | 5.0 | nM | 355.46 | COc1ccc(C2=C(c3ccc(S(N)(=O)=O)cc3)CC3(CC3)C2)cc1 | Homo sapiens | CHEMBL763485 | single protein format |
| CHEMBL5192908 |  |
IC50 | = | 5.0 | nM | 310.34 | COc1ccc(-c2nc(O[11CH3])nn2-c2ccc(OC)cc2)cc1 | Homo sapiens | CHEMBL5152267 | single protein format |
| CHEMBL29204 |  |
IC50 | = | 5.0 | nM | 348.32 | COc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(OC)cc2)cc1 | Homo sapiens | CHEMBL772766 | single protein format |
| CHEMBL2104993 |  |
IC50 | = | 5.19 | nM | 298.46 | Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1 | Homo sapiens | CHEMBL5223370 | single protein format |
| CHEMBL1316 |  |
IC50 | = | 5.3 | nM | 273.72 | CC(C(=O)O)c1ccc2c(c1)[nH]c1ccc(Cl)cc12 | Homo sapiens | CHEMBL5346619 | single protein format |
| CHEMBL404108 |  |
IC50 | = | 7.0 | nM | 293.73 | Cc1ccc(Nc2c(F)cccc2Cl)c(CC(=O)O)c1 | Homo sapiens | CHEMBL2039694 | single protein format |
| CHEMBL26915 |  |
IC50 | = | 7.0 | nM | 352.74 | COc1ccc(-n2nc(C(F)(F)F)cc2-c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL772766 | single protein format |
| CHEMBL80405 |  |
IC50 | = | 7.0 | nM | 365.43 | NS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3)c3ccccc3C2)cc1 | Homo sapiens | CHEMBL664783 | single protein format |
| CHEMBL4476621 |  |
IC50 | = | 8.0 | nM | 356.23 | O=C(NNC(=S)Nc1ccc(Cl)c(Cl)c1)c1ccccc1O | Homo sapiens | CHEMBL4383317 | single protein format |
| CHEMBL1077 |  |
IC50 | = | 8.481 | nM | 334.17 | Nc1c(CC(=O)O)cccc1C(=O)c1ccc(Br)cc1 | Homo sapiens | CHEMBL1909130 | tissue-based format |