P22460 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 (KCNA5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 250~526 | |
| PF02214 | BTB_2 - BTB/POZ domain | 122~212 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4065169 |  |
IC50 | = | 9.0 | nM | 448.52 | CS(=O)(=O)Nc1cccc([C@H](c2ccc(F)cc2)C(c2cccnc2)c2cccnc2)n1 | Homo sapiens | CHEMBL4004499 | single protein format |
| CHEMBL571976 |  |
IC50 | = | 15.0 | nM | 428.3 | CC1=C(c2nc3cc(F)ccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 | Homo sapiens | CHEMBL1039276 | cell-based format |
| CHEMBL3298226 |  |
IC50 | = | 22.0 | nM | 306.41 | COc1cccc2ccnc(NCC(C)(C)c3ccccc3)c12 | Homo sapiens | CHEMBL3364869 | cell-based format |
| CHEMBL3298228 |  |
IC50 | = | 23.0 | nM | 323.4 | COc1cccc2nc(O)nc(NCC(C)(C)c3ccccc3)c12 | Homo sapiens | CHEMBL3364869 | cell-based format |
| CHEMBL4085436 |  |
IC50 | = | 23.0 | nM | 371.87 | Clc1ccccc1-c1ncccc1CC(c1cccnc1)c1cccnc1 | Homo sapiens | CHEMBL4004499 | single protein format |
| CHEMBL3356073 |  |
IC50 | = | 25.0 | nM | 312.44 | COc1cccc2snc(NCC(C)(C)c3ccccc3)c12 | Homo sapiens | CHEMBL3364869 | cell-based format |
| CHEMBL4105245 |  |
IC50 | = | 26.0 | nM | 406.32 | Clc1ccccc1-c1ncccc1CC(c1cccnc1)c1cccnc1Cl | Homo sapiens | CHEMBL4004499 | single protein format |
| CHEMBL3622361 |  |
IC50 | = | 28.0 | nM | 525.55 | COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](NC(=O)OCC(F)(F)F)CC1)=NS2(=O)=O | Homo sapiens | CHEMBL3625774 | cell-based format |
| CHEMBL4104525 |  |
IC50 | = | 29.0 | nM | 422.32 | O[C@@H](c1cccnc1-c1cc(Cl)cc(Cl)c1)C(c1cccnc1)c1cccnc1 | Homo sapiens | CHEMBL4004499 | single protein format |
| CHEMBL1088844 |  |
IC50 | = | 30.0 | nM | 340.45 | CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1P(=O)(c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL1108889 | cell-based format |
| CHEMBL3622355 |  |
IC50 | = | 30.0 | nM | 562.69 | COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](OC(=O)Nc3ccc(N(C)C)cc3)CC1)=NS2(=O)=O | Homo sapiens | CHEMBL3625774 | cell-based format |
| CHEMBL567671 |  |
IC50 | = | 30.0 | nM | 458.32 | COCC1=C(c2nc3cc(F)ccc3n2C)C(c2ccc(Cl)c(Cl)c2)n2nccc2N1 | Homo sapiens | CHEMBL1039276 | cell-based format |
| CHEMBL4062996 |  |
IC50 | = | 30.0 | nM | 371.87 | Clc1cccc(-c2ncccc2CC(c2cccnc2)c2cccnc2)c1 | Homo sapiens | CHEMBL4004499 | single protein format |
| CHEMBL3623054 |  |
IC50 | = | 32.0 | nM | 452.54 | COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](n3cnnn3)CC1)=NS2(=O)=O | Homo sapiens | CHEMBL3625774 | cell-based format |
| CHEMBL4075394 |  |
IC50 | = | 33.0 | nM | 421.42 | FC(F)(F)Oc1cccc(-c2ncccc2CC(c2cccnc2)c2cccnc2)c1 | Homo sapiens | CHEMBL4004499 | single protein format |
| CHEMBL3622346 |  |
IC50 | = | 34.0 | nM | 400.5 | COc1cccc2c1C(NC[C@]1(c3ccccc3)CC[C@H](O)CC1)=NS2(=O)=O | Homo sapiens | CHEMBL3625774 | cell-based format |
| CHEMBL385809 |  |
IC50 | = | 36.0 | nM | 489.64 | CC(C)N(C(=O)C(c1cccnc1)C(CNC(=O)CCc1ccccc1F)c1ccccc1)C(C)C | Homo sapiens | CHEMBL907690 | single protein format |
| CHEMBL2331989 |  |
IC50 | = | 37.0 | nM | 415.33 | CC1=C(c2ncnn2C2CCCC2)[C@@H](c2ccc(Cl)c(Cl)c2)n2nccc2N1 | Homo sapiens | CHEMBL2340853 | cell-based format |
| CHEMBL4521294 |  |
IC50 | = | 40.0 | nM | 389.46 | c1ccc(-c2cccc3nc(-c4ccncc4)nc(NCc4ccccn4)c23)cc1 | Homo sapiens | CHEMBL4431051 | cell-based format |
| CHEMBL4095750 |  |
IC50 | = | 41.0 | nM | 367.45 | COc1cccc(-c2ncccc2CC(c2cccnc2)c2cccnc2)c1 | Homo sapiens | CHEMBL4004499 | single protein format |