P22303 | ACES_HUMAN | Acetylcholinesterase (ACHE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00135 | COesterase - Carboxylesterase family | 39~563 | |
| PF08674 | AChE_tetra - Acetylcholinesterase tetramerisation domain | 578~611 |
3D structures mapped by conservation among orthologs
[ Domain: "alpha/beta-Hydrolases" // COesterase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4579667 |  |
IC50 | = | 5e-06 | nM | 498.67 | O=C(CCCCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccc(O)cc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4469239 |  |
IC50 | = | 5e-06 | nM | 470.69 | S=C(CCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL200008 |  |
IC50 | = | 5e-06 | nM | 519.09 | COc1ccc2[nH]cc(CCNC(=O)CCCCCNc3c4c(nc5cccc(Cl)c35)CCCC4)c2c1 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4467284 |  |
IC50 | = | 5e-06 | nM | 498.74 | S=C(CCCCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL199748 |  |
IC50 | = | 5e-06 | nM | 519.09 | COc1ccc2[nH]cc(CCNC(=O)CCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)c2c1 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4532770 |  |
IC50 | = | 5e-06 | nM | 512.7 | COc1ccc2[nH]cc(CCNC(=O)CCCCCCCNc3c4c(nc5ccccc35)CCCC4)c2c1 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL199454 |  |
IC50 | = | 5e-06 | nM | 484.64 | COc1ccc2[nH]cc(CCNC(=O)CCCCCNc3c4c(nc5ccccc35)CCCC4)c2c1 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4455677 |  |
IC50 | = | 5e-06 | nM | 470.62 | COc1ccc2[nH]cc(CCNC(=O)CCCCNc3c4c(nc5ccccc35)CCCC4)c2c1 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4543251 |  |
IC50 | = | 5e-06 | nM | 472.61 | O=C(CCCCCNc1c2c(nc3ccc(F)cc13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4590945 |  |
IC50 | = | 5e-06 | nM | 551.56 | O=C(CCCCCCCNc1c2c(nc3cc(Cl)cc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL199538 |  |
IC50 | = | 5e-06 | nM | 523.51 | O=C(CCCCCNc1c2c(nc3cc(Cl)cc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4448350 |  |
IC50 | = | 5e-06 | nM | 489.06 | O=C(CCCCCNc1c2c(nc3c(Cl)cccc13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL383663 |  |
IC50 | = | 5e-06 | nM | 489.06 | O=C(CCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4556734 |  |
IC50 | = | 5e-06 | nM | 482.67 | O=C(CCCCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL199861 |  |
IC50 | = | 5e-06 | nM | 454.62 | O=C(CCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4443426 |  |
IC50 | = | 5e-06 | nM | 440.59 | O=C(CCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4468781 |  |
IC50 | = | 5e-06 | nM | 553.53 | COc1ccc2[nH]cc(CCNC(=O)CCCCCNc3c4c(nc5cc(Cl)cc(Cl)c35)CCCC4)c2c1 | Homo sapiens | CHEMBL4342697 | single protein format |
| CHEMBL4451843 |  |
IC50 | = | 0.0076 | nM | 488.64 | O=C(NCCCCCNc1c2c(nc3ccccc13)CCCC2)c1c2ccccc2nc2ccccc12 | Homo sapiens | CHEMBL4326148 | single protein format |
| CHEMBL4589980 |  |
IC50 | = | 0.008 | nM | 503.09 | O=C(CCCCCCNc1c2c(nc3cccc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4391927 | single protein format |
| CHEMBL199585 |  |
IC50 | = | 0.008 | nM | 537.54 | O=C(CCCCCCNc1c2c(nc3cc(Cl)cc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL864026 | single protein format |