P22234 | PUR6_HUMAN | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00731 | AIRC - AIR carboxylase | 267~404 | |
| PF01259 | SAICAR_synt - SAICAR synthetase | 12~238 |
3D structures mapped by conservation among orthologs
[ Domain: "SAICAR synthase" // SAICAR_synt ]
[ Domain: "N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)" // AIRC ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4438093 |  |
IC50 | = | 10.0 | nM | 399.84 | Nc1nc(C(=O)Nc2cc(-c3ccc(OC4CCNC4)nc3)ccc2Cl)co1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4468822 |  |
IC50 | = | 10.0 | nM | 427.89 | Nc1nc(C(=O)Nc2cc(-c3ccc(OCC4CCCNC4)nc3)ccc2Cl)co1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4448446 |  |
IC50 | < | 10.0 | nM | 429.91 | Nc1nc(C(=O)Nc2cc(-c3cnn(CCCN4CCNCC4)c3)ccc2Cl)co1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4459387 |  |
IC50 | = | 10.0 | nM | 374.83 | CCNCCn1cc(-c2ccc(Cl)c(NC(=O)c3coc(N)n3)c2)cn1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4578668 |  |
IC50 | = | 10.0 | nM | 400.87 | Cc1nn(C2CCNCC2)cc1-c1ccc(Cl)c(NC(=O)c2coc(N)n2)c1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4455550 |  |
IC50 | = | 10.0 | nM | 386.84 | Nc1nc(C(=O)Nc2cc(-c3ccn(C4CCNCC4)n3)ccc2Cl)co1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4565482 |  |
IC50 | = | 10.0 | nM | 411.85 | N#Cc1nn(C2CCNCC2)cc1-c1ccc(Cl)c(NC(=O)c2coc(N)n2)c1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4546611 |  |
IC50 | = | 10.0 | nM | 443.94 | CN1CCN(CCCn2cc(-c3ccc(Cl)c(NC(=O)c4coc(N)n4)c3)cn2)CC1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4474352 |  |
IC50 | = | 10.0 | nM | 401.85 | CNCCCOc1ccc(-c2ccc(Cl)c(NC(=O)c3coc(N)n3)c2)cn1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4518584 |  |
IC50 | = | 10.0 | nM | 360.81 | CNCCn1cc(-c2ccc(Cl)c(NC(=O)c3coc(N)n3)c2)cn1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4446674 |  |
IC50 | = | 10.0 | nM | 388.86 | CCNCCCn1cc(-c2ccc(Cl)c(NC(=O)c3coc(N)n3)c2)cn1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4581822 |  |
IC50 | < | 10.0 | nM | 446.96 | CNC1CCCN(Cc2ncc(-c3ccc(Cl)c(NC(=O)c4coc(N)n4)c3)s2)C1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4435251 |  |
IC50 | < | 10.0 | nM | 446.96 | CNC1CCN(Cc2ncc(-c3ccc(Cl)c(NC(=O)c4coc(N)n4)c3)s2)CC1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4463953 |  |
IC50 | < | 10.0 | nM | 418.91 | Nc1nc(C(=O)Nc2cc(-c3nc(CN4CCNCC4)cs3)ccc2Cl)co1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4482890 |  |
IC50 | < | 10.0 | nM | 419.89 | Nc1nc(C(=O)Nc2cc(-c3cnc(OC4CCNCC4)s3)ccc2Cl)co1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4516565 |  |
IC50 | < | 10.0 | nM | 421.91 | CN(C)CCCOc1ncc(-c2ccc(Cl)c(NC(=O)c3coc(N)n3)c2)s1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4446774 |  |
IC50 | < | 10.0 | nM | 414.9 | CNC1CCC(n2cc(-c3ccc(Cl)c(NC(=O)c4coc(N)n4)c3)cn2)CC1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4593253 |  |
IC50 | = | 10.0 | nM | 400.87 | Nc1nc(C(=O)Nc2cc(-c3cnn(CCCNC4CC4)c3)ccc2Cl)co1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4442163 |  |
IC50 | = | 10.0 | nM | 429.91 | CC(C)NCCCOc1ccc(-c2ccc(Cl)c(NC(=O)c3coc(N)n3)c2)cn1 | Homo sapiens | CHEMBL4418466 | single protein format |
| CHEMBL4534524 |  |
IC50 | < | 10.0 | nM | 374.83 | CNCCCn1cc(-c2ccc(Cl)c(NC(=O)c3coc(N)n3)c2)cn1 | Homo sapiens | CHEMBL4418466 | single protein format |