P22102 | PUR2_HUMAN | Trifunctional purine biosynthetic protein adenosine-3 (GART)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00551 | Formyl_trans_N - Formyl transferase | 809~988 | |
| PF00586 | AIRS - AIR synthase related protein, N-terminal domain | 488~593 | |
| PF01071 | GARS_A - Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain | 105~298 | |
| PF02769 | AIRS_C - AIR synthase related protein, C-terminal domain | 607~776 | |
| PF02843 | GARS_C - Phosphoribosylglycinamide synthetase, C domain | 334~424 | |
| PF02844 | GARS_N - Phosphoribosylglycinamide synthetase, N domain | 4~104 |
3D structures mapped by conservation among orthologs
[ Domain: "PurM C-terminal domain-like" // AIRS_C ]
[ Domain: "PurM N-terminal domain-like" // AIRS ]
[ Domain: "ATP-grasp" // ATP-grasp ]
[ Domain: "CO dehydrogenase molybdoprotein N-domain-like" // GARS_C ]
[ Domain: "PreATP-grasp domain" // GARS_N ]
[ Domain: "Formyltransferase" // Formyl_trans_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL279302 |  |
IC50 | = | 5e-05 | nM | 458.48 | Nc1nc(O)c2c(n1)NCC(CCCc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)N2 | Homo sapiens | CHEMBL677841 | single protein format |
| CHEMBL23278 |  |
IC50 | = | 0.00055 | nM | 470.49 | CC(CC1=Nc2c(O)nc(N)nc2NC1)Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL677841 | single protein format |
| CHEMBL23388 |  |
IC50 | = | 0.001 | nM | 459.46 | Nc1nc(O)c2c(n1)NC[C@H](CCNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)N2 | Homo sapiens | CHEMBL677841 | single protein format |
| CHEMBL23699 |  |
IC50 | = | 0.0011 | nM | 472.5 | CC(Cc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)CC1CNc2nc(N)nc(O)c2N1 | Homo sapiens | CHEMBL677841 | single protein format |
| CHEMBL4643623 |  |
IC50 | = | 0.3 | nM | 473.51 | Nc1nc2[nH]c(CCCSc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4624208 | cell-based format |
| CHEMBL4465095 |  |
IC50 | = | 0.7 | nM | 479.49 | Nc1nc2[nH]c(CCCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309300 | cell-based format |
| CHEMBL4636872 |  |
IC50 | = | 0.95 | nM | 456.46 | Nc1nc2[nH]c(CCCNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4624208 | cell-based format |
| CHEMBL4538151 |  |
IC50 | = | 1.0 | nM | 459.43 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309300 | cell-based format |
| CHEMBL4445651 |  |
IC50 | = | 1.2 | nM | 465.46 | Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309300 | cell-based format |
| CHEMBL2158681 |  |
IC50 | = | 1.79 | nM | 461.5 | Nc1nc2[nH]c(CCCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL2161359 | cell-based format |
| CHEMBL4214638 |  |
IC50 | = | 1.8 | nM | 456.46 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)nc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4194647 | cell-based format |
| CHEMBL4557278 |  |
IC50 | = | 2.0 | nM | 474.45 | Nc1nc2[nH]c(CCCCc3cnc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309300 | cell-based format |
| CHEMBL1834488 |  |
IC50 | = | 2.0 | nM | 447.47 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3382019 | cell-based format |
| CHEMBL2158682 |  |
IC50 | = | 2.03 | nM | 461.5 | Nc1nc2[nH]c(CCCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL2161359 | cell-based format |
| CHEMBL4471269 |  |
IC50 | = | 2.11 | nM | 470.44 | Nc1nc2[nH]c(CCN(C=O)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4432158 | cell-based format |
| CHEMBL3628344 |  |
IC50 | = | 2.4 | nM | 447.47 | Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3632393 | cell-based format |
| CHEMBL4645676 |  |
IC50 | = | 2.5 | nM | 457.44 | Nc1nc2[nH]c(CCCOc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4624208 | cell-based format |
| CHEMBL3628346 |  |
IC50 | = | 2.6 | nM | 447.47 | Nc1nc2[nH]c(CCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3632393 | cell-based format |
| CHEMBL4437824 |  |
IC50 | = | 2.64 | nM | 442.43 | Nc1nc2[nH]c(CCNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4432158 | cell-based format |
| CHEMBL3086865 |  |
IC50 | = | 2.89 | nM | 407.43 | Nc1nc2[nH]c(CCCCCCC(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3088992 | cell-based format |