P22001 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 (KCNA3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 237~490 | |
| PF02214 | BTB_2 - BTB/POZ domain | 106~196 |
3D structures mapped by conservation among orthologs
[ Domain: "POZ domain" // BTB_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL16804 |  |
IC50 | = | 5.0 | nM | 424.54 | CCCNC(=O)O[C@H]1CC[C@@](CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 | Homo sapiens | CHEMBL819400 | cell membrane format |
| CHEMBL16806 |  |
IC50 | = | 5.0 | nM | 396.49 | CNC(=O)O[C@H]1CC[C@@](CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 | Homo sapiens | CHEMBL819400 | cell membrane format |
| CHEMBL444449 |  |
IC50 | = | 10.0 | nM | 350.37 | O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 | Homo sapiens | CHEMBL1032475 | cell-based format |
| CHEMBL540249 |  |
IC50 | = | 17.0 | nM | 366.44 | S=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1 | Homo sapiens | CHEMBL1029465 | cell-based format |
| CHEMBL278660 |  |
IC50 | = | 18.0 | nM | 422.53 | C=CCNC(=O)O[C@H]1CC[C@@](CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 | Homo sapiens | CHEMBL819400 | cell membrane format |
| CHEMBL16255 |  |
IC50 | = | 29.0 | nM | 421.54 | C=CCNC(=O)N[C@H]1CC[C@@](CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 | Homo sapiens | CHEMBL819400 | cell membrane format |
| CHEMBL53841 |  |
IC50 | = | 32.0 | nM | 352.91 | CCCCCC/N=c1\ccn(Cc2ccccc2)c2cc(Cl)ccc12 | Homo sapiens | CHEMBL750215 | single protein format |
| CHEMBL293721 |  |
IC50 | = | 47.0 | nM | 348.49 | CCCCCC/N=c1\ccn(Cc2ccccc2)c2ccc(OC)cc12 | Homo sapiens | CHEMBL750215 | single protein format |
| CHEMBL299668 |  |
IC50 | = | 65.0 | nM | 338.88 | CCCCC/N=c1\ccn(Cc2ccccc2)c2cc(Cl)ccc12 | Homo sapiens | CHEMBL750215 | single protein format |
| CHEMBL277598 |  |
IC50 | = | 72.0 | nM | 422.53 | C=CCOC(=O)N[C@H]1CC[C@](CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 | Homo sapiens | CHEMBL819400 | cell membrane format |
| CHEMBL56589 |  |
IC50 | = | 75.0 | nM | 374.92 | CCCCC/N=c1\ccn(-c2ccc3ccccc3c2)c2cc(Cl)ccc12 | Homo sapiens | CHEMBL750215 | single protein format |
| CHEMBL279606 |  |
IC50 | = | 79.0 | nM | 424.54 | CCCNC(=O)O[C@H]1CC[C@](CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 | Homo sapiens | CHEMBL819400 | cell membrane format |
| CHEMBL16683 |  |
IC50 | = | 80.0 | nM | 421.54 | C=CCNC(=O)N[C@H]1CC[C@](CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 | Homo sapiens | CHEMBL819400 | cell membrane format |
| CHEMBL1289186 |  |
IC50 | = | 80.0 | nM | 497.51 | CC(C)(CNC(=O)C1(C(F)(F)F)CC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 | Homo sapiens | CHEMBL1291812 | cell-based format |
| CHEMBL55202 |  |
IC50 | = | 88.0 | nM | 382.94 | CCCCCC/N=c1\ccn(Cc2ccc(OC)cc2)c2cc(Cl)ccc12 | Homo sapiens | CHEMBL750215 | single protein format |
| CHEMBL1289530 |  |
IC50 | = | 90.0 | nM | 511.54 | CC(C)(CNC(=O)C1(C(F)(F)F)CCC1)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 | Homo sapiens | CHEMBL1291812 | cell-based format |
| CHEMBL16945 |  |
IC50 | = | 99.0 | nM | 396.49 | CNC(=O)O[C@H]1CC[C@](CNC(=O)c2ccccc2OC)(c2ccccc2)CC1 | Homo sapiens | CHEMBL819400 | cell membrane format |
| CHEMBL56998 |  |
IC50 | = | 100.0 | nM | 387.35 | CCCCCC/N=c1\ccn(Cc2ccc(Cl)cc2)c2cc(Cl)ccc12 | Homo sapiens | CHEMBL750215 | single protein format |
| CHEMBL54934 |  |
IC50 | = | 117.0 | nM | 366.94 | CCCCCCC/N=c1\ccn(Cc2ccccc2)c2cc(Cl)ccc12 | Homo sapiens | CHEMBL750215 | single protein format |
| CHEMBL1289416 |  |
IC50 | = | 140.0 | nM | 465.5 | CC(C)(CNC(=O)C1CC1(F)F)CN(C1=NS(=O)(=O)c2cc(F)ccc21)c1ccccc1 | Homo sapiens | CHEMBL1291812 | cell-based format |