P21918 | DRD5_HUMAN | D(1B) dopamine receptor (DRD5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 57~359 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1814790 |  |
IC50 | = | 0.15 | nM | 403.86 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C=C\C(=O)O | Homo sapiens | CHEMBL2395016 | single protein format |
| CHEMBL13668 |  |
IC50 | = | 0.56 | nM | 287.79 | CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1 | Homo sapiens | CHEMBL3779716 | cell-based format |
| CHEMBL62 |  |
IC50 | = | 1.1 | nM | 287.79 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1 | Homo sapiens | CHEMBL953140 | single protein format |
| CHEMBL116463 |  |
IC50 | = | 513.0 | nM | 517.62 | N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | Homo sapiens | CHEMBL675948 | single protein format |
| CHEMBL326263 |  |
IC50 | = | 988.0 | nM | 503.59 | N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 | Homo sapiens | CHEMBL675948 | single protein format |
| CHEMBL203637 |  |
Ki | = | 0.057 | nM | 301.82 | CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1 | Homo sapiens | CHEMBL861438 | single protein format |
| CHEMBL1814790 | |
Ki | = | 0.17 | nM | 403.86 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C=C\C(=O)O | Homo sapiens | CHEMBL2395696 | single protein format |
| CHEMBL245764 |  |
Ki | = | 0.23 | nM | 334.46 | COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1 | Homo sapiens | CHEMBL885890 | cell-based format |
| CHEMBL5191141 |  |
Ki | = | 0.37 | nM | 362.97 | [2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCN(C([2H])([2H])[2H])C(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] | Homo sapiens | CHEMBL5117896 | single protein format |
| CHEMBL245570 |  |
Ki | = | 0.39 | nM | 306.41 | CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1 | Homo sapiens | CHEMBL885890 | cell-based format |
| CHEMBL184050 |  |
Ki | = | 0.57 | nM | 283.37 | CN1CCOc2cc(O)ccc2Cc2ccccc2CC1 | Homo sapiens | CHEMBL839546 | single protein format |
| CHEMBL216258 |  |
Ki | = | 0.61 | nM | 304.44 | CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1 | Homo sapiens | CHEMBL912403 | cell-based format |
| CHEMBL5201983 |  |
Ki | = | 0.67 | nM | 345.93 | [2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCNC(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] | Homo sapiens | CHEMBL5117896 | single protein format |
| CHEMBL380464 |  |
Ki | = | 0.98 | nM | 301.82 | CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1 | Homo sapiens | CHEMBL861438 | single protein format |
| CHEMBL599487 |  |
Ki | = | 1.2 | nM | 471.02 | CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1 | Homo sapiens | CHEMBL1073808 | single protein format |
| CHEMBL604314 |  |
Ki | = | 1.4 | nM | 329.83 | CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21 | Homo sapiens | CHEMBL1074770 | cell-based format |
| CHEMBL1204122 |  |
Ki | = | 1.5 | nM | 348.28 | Br.CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | Homo sapiens | CHEMBL858784 | cell-based format |
| CHEMBL201170 |  |
Ki | = | 1.5 | nM | 267.37 | CN1CCc2ccccc2Cc2ccc(O)cc2CC1 | Homo sapiens | CHEMBL861438 | single protein format |
| CHEMBL381936 |  |
Ki | = | 1.68 | nM | 283.37 | CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1 | Homo sapiens | CHEMBL861438 | single protein format |
| CHEMBL184049 |  |
Ki | = | 1.8 | nM | 297.4 | COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2 | Homo sapiens | CHEMBL839546 | single protein format |